vintriptol acid

Base Information

• Chemical Name: vintriptol acid
• CAS No.: 81571-39-3
• Molecular Formula: C₅₄H₆₄N₆O₉
• Molecular Weight: 941.137
• Mol file: 81571-39-3.mol

Synonyms:1H-Indolizino[8,1-cd]carbazole,vincaleukoblastine deriv.; 2H-3,7-Methanoazacycloundecino[5,4-b]indole,vincaleukoblastine deriv.; Vintriptol acid

Chemical Property of vintriptol acid

Chemical Property:

• PKA: 3.67±0.10(Predicted)
• PSA: 207.41000
• Density: 1.44g/cm³
• LogP: 5.32160

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of vintriptol acid

There total 3 articles about vintriptol acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

vinblastine-16-(L)Trp(OMe)-17-OH → vinblastine-16-(L)Trp(OH)-17-OH (81571-39-3)

Guidance literature:

With lithium hydroxide; In methanol; water; at 0 ℃;

DOI:10.1021/bc100028z

Reference yield:

vinblastine-16-hydrazide-17-OH → vinblastine-16-(L)Trp(OH)-17-OH (81571-39-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; sodium nitrite / water

2: dichloromethane; water / 4 °C

3: lithium hydroxide / methanol; water / 0 °C

With hydrogenchloride; lithium hydroxide; sodium nitrite; In methanol; dichloromethane; water;

DOI:10.1021/bc100028z

Reference yield:

vinblastine (72401-36-6) → vinblastine-16-(L)Trp(OH)-17-OH (81571-39-3)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol; chloroform / Reflux

2: hydrogenchloride; sodium nitrite / water

3: dichloromethane; water / 4 °C

4: lithium hydroxide / methanol; water / 0 °C

With hydrogenchloride; hydrazine hydrate; lithium hydroxide; sodium nitrite; In methanol; ethanol; dichloromethane; chloroform; water;

DOI:10.1021/bc100028z

upstream raw materials:

vinblastine

Refernces