(R)-1,2,3,6-tetrahydro-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-<(3-phenylcyclohexen-1-yl)methyl>pyridine

Base Information

Chemical Name:(R)-1,2,3,6-tetrahydro-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-<(3-phenylcyclohexen-1-yl)methyl>pyridine
CAS No.:1026899-47-7
Molecular Formula:C₃₀H₄₁NOSi
Molecular Weight:459.747
Hs Code.:

Synonyms:(R)-1,2,3,6-tetrahydro-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-<(3-phenylcyclohexen-1-yl)methyl>pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1,2,3,6-tetrahydro-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-<(3-phenylcyclohexen-1-yl)methyl>pyridine

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Technology Process of (R)-1,2,3,6-tetrahydro-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-<(3-phenylcyclohexen-1-yl)methyl>pyridine

There total 7 articles about (R)-1,2,3,6-tetrahydro-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-<(3-phenylcyclohexen-1-yl)methyl>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-piperidin-4-ol

: 1026899-47-7
(R)-1,2,3,6-tetrahydro-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-<(3-phenylcyclohexen-1-yl)methyl>pyridine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h; Yield given; Ambient temperature;

Reference yield:

: 67963-68-2
t-butyldimethylsilyl-4-bromophenol

: 1026899-47-7
(R)-1,2,3,6-tetrahydro-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-<(3-phenylcyclohexen-1-yl)methyl>pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) s-BuLi / 1.) cyclohexane, THF, -78 deg C, 30 min, 2.) cyclohexane, THF, -78 deg C, 3 h

2: CF₃CO₂H / CH₂Cl₂ / 1 h / Ambient temperature

With sec.-butyllithium; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 1026899-47-7
(R)-1,2,3,6-tetrahydro-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-<(3-phenylcyclohexen-1-yl)methyl>pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) isobutyl chloroformate, Et₃N / 1.) CH₂Cl₂, -20 deg C, 30 min, 2.) CH₂Cl₂, 25 deg C, overnight

2: AlCl₃, LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h / 0 °C

3: 2 N HCl / tetrahydrofuran / 2 h / Heating

4: 1.) s-BuLi / 1.) cyclohexane, THF, -78 deg C, 30 min, 2.) cyclohexane, THF, -78 deg C, 3 h

5: CF₃CO₂H / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; aluminium trichloride; sec.-butyllithium; triethylamine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; diethyl ether; dichloromethane;