bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} icosanedioate

Base Information

Chemical Name:bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} icosanedioate
CAS No.:1622913-89-6
Molecular Formula:C₆₂H₈₀Cl₂F₂N₂O₆
Molecular Weight:1058.23
Hs Code.:

Synonyms:bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} icosanedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} icosanedioate

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Technology Process of bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} icosanedioate

There total 2 articles about bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} icosanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52-86-8
haloperidol

: 101702-50-5
1,20-eicosanedioyl dichloride

: 1622913-89-6
bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} icosanedioate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.06.079

Reference yield:

: 2424-92-2
octadecane-1,18-dicarboxylic acid

: 1622913-89-6
bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} icosanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2014.06.079