((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)amine

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Chemical Name:((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)amine
CAS No.:1351338-52-7
Molecular Formula:C₂₅H₃₁ClFN₇O₂
Molecular Weight:516.018
Hs Code.:

Synonyms:((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)amine

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Chemical Property of ((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)amine

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Technology Process of ((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)amine

There total 8 articles about ((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351345-53-3
((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester

: 1351338-52-7
((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)amine

Guidance literature:: ((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydroxide; In ethyl acetate;

Reference yield:

: 6457-49-4
4-piperidinemethanol

: 1351338-52-7
((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 2.17 h / 0 - 20 °C

2.1: zinc(II) chloride / ethanol / 2.25 h / 20 °C

2.2: 18 h / 50 °C

2.3: pH 7

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 120 h / 85 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 20 °C

With sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; zinc(II) chloride; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1032825-19-6
(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methyl methanesulfonate

: 1351338-52-7
((3R,4S)-4-(4-chloro-2-fluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 120 h / 85 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 20 °C

With potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;