(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-hydroxyisoandrosterone

Base Information

Chemical Name:(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-hydroxyisoandrosterone
CAS No.:1430077-85-2
Molecular Formula:C₃₅H₄₈O₃Si
Molecular Weight:544.85
Hs Code.:

Synonyms:(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-hydroxyisoandrosterone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-hydroxyisoandrosterone

Chemical Property:

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Technology Process of (3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-hydroxyisoandrosterone

There total 3 articles about (3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-hydroxyisoandrosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₄₇BrO₂Si

: 1430077-85-2
(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-hydroxyisoandrosterone

Guidance literature:: With water; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol4004993

Reference yield:

: 481-29-8
Epiandrosterone

: 1430077-85-2
(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-hydroxyisoandrosterone

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) bromide / methanol / Reflux; Inert atmosphere

2: 1H-imidazole; dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: water; sodium hydroxide / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; water; sodium hydroxide; copper(ll) bromide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol4004993

Reference yield:

: 74310-74-0
16-bromoepiandrosterone

: 1430077-85-2
(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-hydroxyisoandrosterone

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole; dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: water; sodium hydroxide / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; water; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol4004993