allyl [5'-O-(p,p'-dimethoxytrityl)thymidylyl]-(3'-5')-3'-O-[(allyloxy)carbonyl]thymidine

Base Information

Chemical Name:allyl [5'-O-(p,p'-dimethoxytrityl)thymidylyl]-(3'-5')-3'-O-[(allyloxy)carbonyl]thymidine
CAS No.:183378-42-9
Molecular Formula:C₄₈H₅₃N₄O₁₆P
Molecular Weight:972.94
Hs Code.:

Synonyms:allyl [5'-O-(p,p'-dimethoxytrityl)thymidylyl]-(3'-5')-3'-O-[(allyloxy)carbonyl]thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of allyl [5'-O-(p,p'-dimethoxytrityl)thymidylyl]-(3'-5')-3'-O-[(allyloxy)carbonyl]thymidine

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Technology Process of allyl [5'-O-(p,p'-dimethoxytrityl)thymidylyl]-(3'-5')-3'-O-[(allyloxy)carbonyl]thymidine

There total 7 articles about allyl [5'-O-(p,p'-dimethoxytrityl)thymidylyl]-(3'-5')-3'-O-[(allyloxy)carbonyl]thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 104655-82-5
5'-O-(p,p'-dimethoxytrityl)thymidine 3'-(allyl N,N-diisopropylphosphoramidite)

: 102423-19-8
Carbonic acid allyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 183378-42-9
allyl [5'-O-(p,p'-dimethoxytrityl)thymidylyl]-(3'-5')-3'-O-[(allyloxy)carbonyl]thymidine

Guidance literature:: With tert.-butylhydroperoxide; benzimidazolium trifluoromethanesulfonate; In toluene; acetonitrile; at 25 ℃; for 0.1h; Product distribution; multistep reaction; other reagent, reaction time;
DOI:10.1021/jo961569e

Reference yield:

: 183378-48-5,183509-71-9
C₄₀H₄₅N₄PO₁₁(CO₂C₃H₄)2

: 183378-42-9
allyl [5'-O-(p,p'-dimethoxytrityl)thymidylyl]-(3'-5')-3'-O-[(allyloxy)carbonyl]thymidine

Guidance literature:: With tert.-butylhydroperoxide; In toluene; acetonitrile; at 25 ℃; for 0.0833333h; Yield given;
DOI:10.1021/jo961569e

Reference yield:

: 104655-82-5
5'-O-(p,p'-dimethoxytrityl)thymidine 3'-(allyl N,N-diisopropylphosphoramidite)

: 183378-42-9
allyl [5'-O-(p,p'-dimethoxytrityl)thymidylyl]-(3'-5')-3'-O-[(allyloxy)carbonyl]thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: benzimidazolium triflate; 3 Angstroem molecular sieves / acetonitrile / 0.02 h / 25 °C

2: ethyl(methyl)dioxirane; dimethyl phthalate / acetonitrile; CH₂Cl₂ / 0.08 h / 25 °C

With phthalic acid dimethyl ester; 3 A molecular sieve; ethylmethyldioxirane; benzimidazolium trifluoromethanesulfonate; In dichloromethane; acetonitrile;
DOI:10.1021/ol000364w