methyl 2-(2-acetamidopropanamido)-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carboxylate

Base Information

Chemical Name:methyl 2-(2-acetamidopropanamido)-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carboxylate
CAS No.:1369514-64-6
Molecular Formula:C₂₀H₂₀N₄O₅
Molecular Weight:396.403
Hs Code.:

Synonyms:methyl 2-(2-acetamidopropanamido)-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carboxylate

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Chemical Property of methyl 2-(2-acetamidopropanamido)-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carboxylate

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Technology Process of methyl 2-(2-acetamidopropanamido)-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carboxylate

There total 7 articles about methyl 2-(2-acetamidopropanamido)-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 15962-47-7,27395-26-2,64397-30-4,71806-49-0
N-acetyl-D,L-alanineamide

: 1369514-52-2
methyl 2-chloro-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carboxylate

: 1369514-64-6
methyl 2-(2-acetamidopropanamido)-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 140 ℃; for 0.75h; Microwave irradiation;
DOI:10.1016/j.tet.2012.02.022

Reference yield:

: 1011736-32-5
C₂₁H₁₇ClN₂O₂

: 1369514-64-6
methyl 2-(2-acetamidopropanamido)-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: iodine / dichloromethane / 0.25 h / 20 °C

2.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / tetrahydrofuran / 0.42 h / 160 °C / Microwave irradiation

3.1: 4-methyl-morpholine; osmium(VIII) oxide; water / acetone; tert-butyl alcohol / Inert atmosphere

4.1: sodium periodate / tetrahydrofuran; water / 7 h / 20 °C

5.1: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; water / tert-butyl alcohol / 1 h / 20 °C

5.2: pH 2

6.1: toluene-4-sulfonic acid / 125 °C / Microwave irradiation

7.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / tetrahydrofuran / 0.75 h / 140 °C / Microwave irradiation

With 4-methyl-morpholine; sodium chlorite; sodium periodate; osmium(VIII) oxide; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; water; iodine; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol; 7.1: Buchwald-Hartwig amidation;
DOI:10.1016/j.tet.2012.02.022

Reference yield:

: 1369514-45-3
2-chloro-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carbaldehyde

: 1369514-64-6
methyl 2-(2-acetamidopropanamido)-3-methyl-6-phenylfuro[3,2-b]pyrazine-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; water / tert-butyl alcohol / 1 h / 20 °C

1.2: pH 2

2.1: toluene-4-sulfonic acid / 125 °C / Microwave irradiation

3.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / tetrahydrofuran / 0.75 h / 140 °C / Microwave irradiation

With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; water; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; tert-butyl alcohol; 3.1: Buchwald-Hartwig amidation;
DOI:10.1016/j.tet.2012.02.022