N²-[1-(2,3,4-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrenyl)]-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Base Information

• Chemical Name: N²-[1-(2,3,4-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrenyl)]-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine
• CAS No.: 945548-64-1
• Molecular Formula: C₆₈H₇₃N₅O₁₀Si₂
• Molecular Weight: 1176.53

Synonyms:N²-[1-(2,3,4-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrenyl)]-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Chemical Property of N²-[1-(2,3,4-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrenyl)]-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-[1-(2,3,4-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrenyl)]-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

There total 4 articles about N²-[1-(2,3,4-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrenyl)]-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(+/-)-1β-amino-2α,3α,4β-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene + 2-bromo-6-benzyloxy-9-[2-deoxy-3,5-bis(O-tert-butyldimethylsilyl)-β-D-erythro-pentofuranosyl]purine (236427-58-0) → N2-[1-(2,3,4-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrenyl)]-O6-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (945548-64-1)

Guidance literature:

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene; at 85 ℃; for 16h;

DOI:10.1021/jo070204z

Reference yield:

(+/-)-1β-azido-2α,3α,4β-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene → N2-[1-(2,3,4-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrenyl)]-O6-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (945548-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / hydrogen / Lindlar catalyst / tetrahydrofuran; ethanol / 2.33 h / 20 °C / 760.05 Torr

2: 70 percent / Cs₂CO₃; (+/-)-BINAP / Pd(OAc)2 / toluene / 16 h / 85 °C

With hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; Lindlar's catalyst; In tetrahydrofuran; ethanol; toluene;

DOI:10.1021/jo070204z

Reference yield:

(+/-)-1β-azido-2α,3α,4β-trihydroxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene → N2-[1-(2,3,4-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrenyl)]-O6-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (945548-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / triethylamine / dimethylformamide / 0.75 h / 20 °C

2: 87 percent / hydrogen / Lindlar catalyst / tetrahydrofuran; ethanol / 2.33 h / 20 °C / 760.05 Torr

3: 70 percent / Cs₂CO₃; (+/-)-BINAP / Pd(OAc)2 / toluene / 16 h / 85 °C

With hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; palladium diacetate; Lindlar's catalyst; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo070204z

upstream raw materials:

2-bromo-6-benzyloxy-9-[2-deoxy-3,5-bis(O-tert-butyldimethylsilyl)-β-D-erythro-pentofuranosyl]purine

(+/-)-3α,4β-dihydroxy-1α,2α-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 945548-64-1 N²-[1-(2,3,4-trisbenzoyloxy-1,2,3,4-tetrahydrobenzo[c]phenanthrenyl)]-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send