2-Chloro-5,6-difluoro-1-(2,3,5-tri-O-acetyl-α-D-ribofuranosyl)benzimidazole

Base Information

Chemical Name:2-Chloro-5,6-difluoro-1-(2,3,5-tri-O-acetyl-α-D-ribofuranosyl)benzimidazole
CAS No.:142395-44-6
Molecular Formula:C₁₈H₁₇ClF₂N₂O₇
Molecular Weight:446.792
Hs Code.:

Synonyms:2-Chloro-5,6-difluoro-1-(2,3,5-tri-O-acetyl-α-D-ribofuranosyl)benzimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Chloro-5,6-difluoro-1-(2,3,5-tri-O-acetyl-α-D-ribofuranosyl)benzimidazole

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Technology Process of 2-Chloro-5,6-difluoro-1-(2,3,5-tri-O-acetyl-α-D-ribofuranosyl)benzimidazole

There total 1 articles about 2-Chloro-5,6-difluoro-1-(2,3,5-tri-O-acetyl-α-D-ribofuranosyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76179-40-3
2-amino-4,5-difluoroaniline

: 142395-44-6
2-Chloro-5,6-difluoro-1-(2,3,5-tri-O-acetyl-α-D-ribofuranosyl)benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / acetonitrile; H₂O; methanol / 2 h / Ambient temperature

2: 59 percent / aq. CuCl₂, NaNO₂ / a) RT, 1 h, b) 100 deg C, 10 min

3: 1.) BSA, 2.) TMSOTf / 1.) ClCH₂CH₂Cl, 75 deg C, 30 min, 2.) ClCH₂CH₂Cl, 75 deg C, 30 min

With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; copper dichloride; sodium nitrite; In methanol; water; acetonitrile;
DOI:10.1021/jm960462g