2-(2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-4-yl)-propan-2-ol

Base Information

Chemical Name:2-(2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-4-yl)-propan-2-ol
CAS No.:1201673-82-6
Molecular Formula:C₂₃H₃₃N₅O
Molecular Weight:395.548
Hs Code.:

Synonyms:2-(2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-4-yl)-propan-2-ol

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Chemical Property of 2-(2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-4-yl)-propan-2-ol

Chemical Property:

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Technology Process of 2-(2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-4-yl)-propan-2-ol

There total 10 articles about 2-(2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-4-yl)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201675-30-0
4-[2'-cyclohexylamino-4-(1-hydroxy-1-methylethyl)-[2,4']bipyridinyl-6-yl]-piperazine-1-carboxylic acid tert-butyl ester

: 1201673-82-6
2-(2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-4-yl)-propan-2-ol

Guidance literature:: 4-[2'-cyclohexylamino-4-(1-hydroxy-1-methylethyl)-[2,4']bipyridinyl-6-yl]-piperazine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 1h;

With ammonium hydroxide; In water; acetonitrile;

Reference yield:

: 1201674-99-8
2-cyclohexylamino-4-iodopyridine

: 1201673-82-6
2-(2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-4-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

2: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 h / 100 °C

3: tetrahydrofuran / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h

With cesium fluoride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 1201674-98-7
cyclohexyl-(4-trimethylstannanylpyridin-2-yl)amine

: 1201673-82-6
2-(2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-4-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 h / 100 °C

2: tetrahydrofuran / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h

With cesium fluoride; trifluoroacetic acid; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane;