16χ-(2-aminophenyl)-3α-(1-hydroxy-1-methylethyl)-8,14-dimethyl-18-nor-4-oxa-5β,8α,9β,10α,13α,14β-androstan-15-one

Base Information

Chemical Name:16χ-(2-aminophenyl)-3α-(1-hydroxy-1-methylethyl)-8,14-dimethyl-18-nor-4-oxa-5β,8α,9β,10α,13α,14β-androstan-15-one
CAS No.:95217-64-4
Molecular Formula:C₂₈H₄₁NO₃
Molecular Weight:439.638
Hs Code.:

Synonyms:16χ-(2-aminophenyl)-3α-(1-hydroxy-1-methylethyl)-8,14-dimethyl-18-nor-4-oxa-5β,8α,9β,10α,13α,14β-androstan-15-one

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Chemical Property of 16χ-(2-aminophenyl)-3α-(1-hydroxy-1-methylethyl)-8,14-dimethyl-18-nor-4-oxa-5β,8α,9β,10α,13α,14β-androstan-15-one

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Technology Process of 16χ-(2-aminophenyl)-3α-(1-hydroxy-1-methylethyl)-8,14-dimethyl-18-nor-4-oxa-5β,8α,9β,10α,13α,14β-androstan-15-one

There total 44 articles about 16χ-(2-aminophenyl)-3α-(1-hydroxy-1-methylethyl)-8,14-dimethyl-18-nor-4-oxa-5β,8α,9β,10α,13α,14β-androstan-15-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 120174-22-3,120174-23-4,120292-96-8,120292-97-9
(3S,5S,8S,9R,10S,13S,14S)-16-(2-Amino-phenyl)-3-(1-hydroxy-1-methyl-ethyl)-8,10,14-trimethyl-16-methylsulfanyl-tetradecahydro-4-oxa-cyclopenta[a]phenanthren-15-one

: 95217-64-4
16χ-(2-aminophenyl)-3α-(1-hydroxy-1-methylethyl)-8,14-dimethyl-18-nor-4-oxa-5β,8α,9β,10α,13α,14β-androstan-15-one

Guidance literature:: With nickel; In ethanol; for 0.5h;
DOI:10.1021/jo00275a035

Reference yield:

: 95217-46-2
3α-(1-hydroxy-1-methylethyl)-8,14-dimethyl-18-nor-4-oxa-5β,8α,9β,10α,13α,14β-androstan-15-one

: 95217-64-4
16χ-(2-aminophenyl)-3α-(1-hydroxy-1-methylethyl)-8,14-dimethyl-18-nor-4-oxa-5β,8α,9β,10α,13α,14β-androstan-15-one

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide

With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja00292a058

Reference yield:

: 95217-58-6,95248-90-1,120174-26-7,120174-34-7
5α-hydroxy-4,8,14-trimethyl-4,5-seco-18-nor-8α,9β,13α,14β-androst-3-en-15-one

: 95217-64-4
16χ-(2-aminophenyl)-3α-(1-hydroxy-1-methylethyl)-8,14-dimethyl-18-nor-4-oxa-5β,8α,9β,10α,13α,14β-androstan-15-one

Guidance literature:: Multi-step reaction with 5 steps

1: mCPBA / CH₂Cl₂

2: 1.) PCC, molecular sieves (4 Angstroem); 2.) K₂CO₃ / 1.) CH₂Cl₂; 2.) MeOH

3: 80 percent / diethyl ether; tetrahydrofuran

4: 92 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide

With 4 A molecular sieve; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane;
DOI:10.1021/ja00292a058