N-trityl-L-pyroglutamyl-L-histidyl(N^im-trityl)-trans-4-hydroxy-L-proline methyl ester

Base Information

• Chemical Name: N-trityl-L-pyroglutamyl-L-histidyl(N^im-trityl)-trans-4-hydroxy-L-proline methyl ester
• CAS No.: 164166-93-2
• Molecular Formula: C₅₅H₅₁N₅O₆
• Molecular Weight: 878.04

Synonyms:N-trityl-L-pyroglutamyl-L-histidyl(N^im-trityl)-trans-4-hydroxy-L-proline methyl ester

Chemical Property of N-trityl-L-pyroglutamyl-L-histidyl(N^im-trityl)-trans-4-hydroxy-L-proline methyl ester

Chemical Property:

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Technology Process of N-trityl-L-pyroglutamyl-L-histidyl(N^im-trityl)-trans-4-hydroxy-L-proline methyl ester

There total 2 articles about N-trityl-L-pyroglutamyl-L-histidyl(N^im-trityl)-trans-4-hydroxy-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-4-hydroxyproline methyl ester hydrochloride (40216-83-9) + N-trityl-L-pyroglutamyl-L-(Nim-trityl)histidine (164166-91-0) → N-trityl-L-pyroglutamyl-D-histidyl(Nim-trityl)-trans-4-hydroxy-L-proline methyl ester (164167-01-5,164167-02-6) + N-trityl-L-pyroglutamyl-L-histidyl(Nim-trityl)-trans-4-hydroxy-L-proline methyl ester (164166-93-2)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h; Ambient temperature;

Reference yield:

L-4-hydroxyproline methyl ester hydrochloride (40216-83-9) + Trt-Glp-D-His(Trt)-OH (164166-99-8) → N-trityl-L-pyroglutamyl-D-histidyl(Nim-trityl)-trans-4-hydroxy-L-proline methyl ester (164167-01-5,164167-02-6) + N-trityl-L-pyroglutamyl-L-histidyl(Nim-trityl)-trans-4-hydroxy-L-proline methyl ester (164166-93-2)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, from 0 deg C to RT, 1 h, 2.) DMF, RT, 1 h;

Reference yield: 96.0%

N-trityl-L-pyroglutamyl-L-histidyl(Nim-trityl)-trans-4-hydroxy-L-proline methyl ester (164166-93-2) → (2S,4R)-4-Hydroxy-1-[(S)-2-[((S)-5-oxo-1-trityl-pyrrolidine-2-carbonyl)-amino]-3-(1-trityl-1H-imidazol-4-yl)-propionyl]-pyrrolidine-2-carboxylic acid

Guidance literature:

With sodium hydroxide; In methanol; at 0 - 20 ℃; for 2.75h;

upstream raw materials:

L-4-hydroxyproline methyl ester hydrochloride

Trt-Glp-D-His(Trt)-OH

N-trityl-L-pyroglutamyl-L-(N^im-trityl)histidine

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