ethyl (2E)-3-{2-[1-(3-ethoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate

Base Information

Chemical Name:ethyl (2E)-3-{2-[1-(3-ethoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate
CAS No.:1401416-10-1
Molecular Formula:C₂₀H₂₈O₇
Molecular Weight:380.438
Hs Code.:

Synonyms:ethyl (2E)-3-{2-[1-(3-ethoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate

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Chemical Property of ethyl (2E)-3-{2-[1-(3-ethoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate

Chemical Property:

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Technology Process of ethyl (2E)-3-{2-[1-(3-ethoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate

There total 3 articles about ethyl (2E)-3-{2-[1-(3-ethoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₂₁BrO₅

: 140-88-5,9003-32-1
ethyl acrylate

: 1401416-10-1
ethyl (2E)-3-{2-[1-(3-ethoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate

Guidance literature:: With palladium diacetate; triphenylphosphine; In toluene; at 80 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.08.023

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 1401416-10-1
ethyl (2E)-3-{2-[1-(3-ethoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate

Guidance literature:: Multi-step reaction with 3 steps

2: caesium carbonate / toluene / 48 h / 50 °C / Inert atmosphere

3: palladium diacetate; triphenylphosphine / toluene / 24 h / 80 °C / Inert atmosphere

With palladium diacetate; caesium carbonate; triphenylphosphine; In toluene; 1: |Grignard Reaction / 2: |Michael Addition / 3: |Heck Reaction;
DOI:10.1016/j.tetlet.2012.08.023

Reference yield:

: 5293-52-7
6-bromo-3,4-dimethoxy-α-methylbenzyl alcohol

: 140-88-5,9003-32-1
ethyl acrylate

: 1401416-10-1
ethyl (2E)-3-{2-[1-(3-ethoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / toluene / 48 h / 50 °C / Inert atmosphere

2: palladium diacetate; triphenylphosphine / toluene / 24 h / 80 °C / Inert atmosphere

With palladium diacetate; caesium carbonate; triphenylphosphine; In toluene; 1: |Michael Addition / 2: |Heck Reaction;
DOI:10.1016/j.tetlet.2012.08.023