Pristinamycin

Base Information

• Chemical Name: Pristinamycin
• CAS No.: 11006-76-1
• Molecular Formula: Unspecified
• Molecular Weight: 1349.48000
• Hs Code.: 2941900000
• European Community (EC) Number: 234-244-6,686-746-3
• NSC Number: 246121
• Wikipedia: Pristinamycin,Virginiamycin
• NCI Thesaurus Code: C937,C166769
• Mol file: 11006-76-1.mol

Synonyms:Pristinamycin;Pyostacine;RP 7293;RP7293

Chemical Property of Pristinamycin

Chemical Property:

• Appearance/Colour: White solid
• Melting Point: 170-178oC
• PSA: 363.76000
• LogP: 4.99230
• Storage Temp.: Amber Vial, Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 19
• Rotatable Bond Count: 7
• Exact Mass: 1348.60159125
• Heavy Atom Count: 98
• Complexity: 2640

Purity/Quality:

50% ^*data from raw suppliers

Virginiamycin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Uses -> Pharmaceuticals
• Canonical SMILES: CCC1C(=O)N2CCCC2C(=O)N(C(C(=O)N3CCC(=O)CC3C(=O)NC(C(=O)OC(C(C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=CC=C6)C.CC1C=CC(=O)NCC=CC(=CC(CC(=O)CC2=NC(=CO2)C(=O)N3CCC=C3C(=O)OC1C(C)C)O)C
• Isomeric SMILES: CCC1C(=O)N2CCCC2C(=O)N(C(C(=O)N3CCC(=O)CC3C(=O)NC(C(=O)OC(C(C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=CC=C6)C.CC1/C=C\C(=O)NC/C=C\C(=C/C(CC(=O)CC2=NC(=CO2)C(=O)N3CCC=C3C(=O)OC1C(C)C)O)\C
• Recent ClinicalTrials: Study to Compare the Efficacy of Pristinamycin (Pyostacine ?) Versus Amoxicillin in the Treatment of Acute Community Acquired Pneumonia
• Recent EU Clinical Trials: ANTIBIOTIC THERAPY IN RESPIRATORY TRACT INFECTIONS: AIR.
• Uses: Virginiamycin is a mixture of Virginiamycin S1 and Virginiamycin M1 (V673810). It is an antibiotic used in livestock feed to prevent disease among young swine. Also is used in ethanol production to prevent microbial contamination. Virginiamycin complex is defined as a mixture of 75% ostreogrycin A (virginiamycin M1) and 25% virginiamycin S1, together with the less abundant S analogues. As the two major components have quite different solubilities, these proportions are not readily achieved or used. BioAustralis has isolated and re-combined the individual components to provide the defined components of virginiamycin complex. The composition of the complex is important as Virginiamycin S1 acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A. Occupational dermatitis was observed in the pharmaceutical industry and in a surgeon who used topical virginiamycin on postoperative wounds (CJ Le Coz, unpublished observations). Pristinamycin is a mixture of two components that have a synergistic antibacterial action. The two components are Pristinamycin IIA (V673810) and Pristinamycin IA (P745000).