(Z)-2-(2-Chloro-4-hydroxy-quinolin-3-yl)-3-(4-chloro-phenyl)-acrylic acid

Base Information

Chemical Name:(Z)-2-(2-Chloro-4-hydroxy-quinolin-3-yl)-3-(4-chloro-phenyl)-acrylic acid
CAS No.:131469-56-2
Molecular Formula:C₁₈H₁₁Cl₂NO₃
Molecular Weight:360.196
Hs Code.:

Synonyms:(Z)-2-(2-Chloro-4-hydroxy-quinolin-3-yl)-3-(4-chloro-phenyl)-acrylic acid

Suppliers and Price of (Z)-2-(2-Chloro-4-hydroxy-quinolin-3-yl)-3-(4-chloro-phenyl)-acrylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Z)-2-(2-Chloro-4-hydroxy-quinolin-3-yl)-3-(4-chloro-phenyl)-acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Z)-2-(2-Chloro-4-hydroxy-quinolin-3-yl)-3-(4-chloro-phenyl)-acrylic acid

There total 4 articles about (Z)-2-(2-Chloro-4-hydroxy-quinolin-3-yl)-3-(4-chloro-phenyl)-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 131469-36-8
4-Chloro-3-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-3H-furo[3,2-c]quinolin-2-one

: 131469-56-2
(Z)-2-(2-Chloro-4-hydroxy-quinolin-3-yl)-3-(4-chloro-phenyl)-acrylic acid

Guidance literature:: With potassium hydroxide; at 100 ℃; for 0.5h;
DOI:10.1055/s-1990-27017

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 131469-56-2
(Z)-2-(2-Chloro-4-hydroxy-quinolin-3-yl)-3-(4-chloro-phenyl)-acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Ac₂O / acetic acid / 6 h / 140 °C

2: 78 percent / POCl₃ / 2 h / 110 °C / Heating

3: 80 percent / aq. KOH / 0.5 h / 100 °C

With potassium hydroxide; acetic anhydride; trichlorophosphate; In acetic acid;
DOI:10.1055/s-1990-27017

Reference yield:

: 96838-79-8
1H-4-hydroxy-2-oxoquinoline-3-acetic acid

: 131469-56-2
(Z)-2-(2-Chloro-4-hydroxy-quinolin-3-yl)-3-(4-chloro-phenyl)-acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Ac₂O / acetic acid / 6 h / 140 °C

2: 78 percent / POCl₃ / 2 h / 110 °C / Heating

3: 80 percent / aq. KOH / 0.5 h / 100 °C

With potassium hydroxide; acetic anhydride; trichlorophosphate; In acetic acid;
DOI:10.1055/s-1990-27017