3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzoic acid hydrochloride

Base Information

Chemical Name:3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzoic acid hydrochloride
CAS No.:1150262-45-5
Molecular Formula:C₁₅H₁₂F₃NO₃*ClH
Molecular Weight:347.721
Hs Code.:

Synonyms:3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzoic acid hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzoic acid hydrochloride

Chemical Property:

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Technology Process of 3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzoic acid hydrochloride

There total 1 articles about 3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1150262-44-4
tert-butyl 3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzoate

: 1150262-45-5
3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1202070-39-0,1955519-79-5
(1R)-1-(5-fluoropyridin-2-yl)ethanamine hydrochloride

: 1150262-45-5
3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzoic acid hydrochloride

: 76-05-1
trifluoroacetic acid

: N-[(1R)-1-(5-fluoropyridin-2-yl)ethyl]-3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzamide trifluoroacetate

Guidance literature:: (1R)-1-(5-fluoropyridin-2-yl)ethanamine hydrochloride; 3-(5-methylpyridin-2-yl)-5-[(RS)-2,2,2-trifluoro-1-hydroxyethyl]benzoic acid hydrochloride; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

trifluoroacetic acid; In water; acetonitrile;