3',5'-O-Dipalmitoyl-5-fluoro-2'-deoxyuridine

Base Information

• Chemical Name: 3',5'-O-Dipalmitoyl-5-fluoro-2'-deoxyuridine
• CAS No.: 7207-68-3
• Molecular Formula: C₄₁H₇₁FN₂O₇
• Molecular Weight: 723.022
• Nikkaji Number: J504.547I
• Mol file: 7207-68-3.mol

Synonyms:3',5'-O-dipalmitoyl-5-fluoro-2'-deoxyuridine;3,5-dipalmitoyl-FUDR;5-fluoro-2'-deoxy-O',O'-dipalmitoyluridine

Chemical Property of 3',5'-O-Dipalmitoyl-5-fluoro-2'-deoxyuridine

Chemical Property:

• PSA: 127.95000
• LogP: 10.18150
• XLogP3: 14.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 34
• Exact Mass: 722.52453077
• Heavy Atom Count: 51
• Complexity: 1010

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCC1C(CC(O1)N2C=C(C(=O)NC2=O)F)OC(=O)CCCCCCCCCCCCCCC
• Isomeric SMILES: CCCCCCCCCCCCCCCC(=O)OC[C@@H]1[C@H](C[C@@H](O1)N2C=C(C(=O)NC2=O)F)OC(=O)CCCCCCCCCCCCCCC

Technology Process of 3',5'-O-Dipalmitoyl-5-fluoro-2'-deoxyuridine

There total 1 articles about 3',5'-O-Dipalmitoyl-5-fluoro-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl palmitate (693-38-9) + 5-Fluoro-2'-deoxyuridine (50-91-9) → 5'-O-palmitoyl-floxuridine (96733-83-4) + 3'-O-palmitoyl-floxuridine (96733-84-5) + 3',5'-di-O-palmitoyl-FUdR (7207-68-3)

Guidance literature:

With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate; In tetrahydrofuran; at 50 ℃; regioselective reaction;

DOI:10.1016/j.tet.2008.11.045

upstream raw materials:

vinyl palmitate

5-Fluoro-2'-deoxyuridine

Refernces

• 1、 Li, Ning,Zong, Min-Hua,Ma, Ding. "Regioselective acylation of nucleosides catalyzed by candida antarctica lipase B: Enzyme substrate recognition". supporting information; scheme or table. p. 5375 - 5378. Retrieved 2009/05/07.