(Z)-(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone oxime

Base Information

Chemical Name:(Z)-(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone oxime
CAS No.:1428882-08-9
Molecular Formula:C₁₆H₁₀F₂N₄O₂
Molecular Weight:328.278
Hs Code.:

Synonyms:(Z)-(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone oxime

Suppliers and Price of (Z)-(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone oxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Z)-(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone oxime

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Z)-(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone oxime

There total 5 articles about (Z)-(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.2%

: 1428882-07-8
(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone

: 1428882-08-9
(Z)-(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone oxime

Guidance literature:: With pyridine; hydroxylamine hydrochloride; for 1.5h; Reflux;

Reference yield:

: 97509-75-6
3-fluoropicolinonitrile

: 1428882-08-9
(Z)-(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone oxime

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; diisopropylamine; lithium diisopropyl amide / tetrahydrofuran / 0.58 h / -78 °C

1.2: 0.75 h

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 17 h / 85 °C / Inert atmosphere

3.1: peracetic acid; sulfuric acid / acetone / 1 h / Reflux

4.1: tetrahydrofuran / 0 - 20 °C

5.1: pyridine; hydroxylamine hydrochloride / 1.5 h / Reflux

With pyridine; peracetic acid; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; hydroxylamine hydrochloride; caesium carbonate; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; acetone;

Reference yield:

: 1428882-00-1
3-fluoro-4-(pyrimidin-5-yl)picolinonitrile

: 1428882-08-9
(Z)-(3-fluoro-4-(4-hydroxypyrimidin-5-yl)pyridin-2-yl)(4-fluorophenyl)methanone oxime

Guidance literature:: Multi-step reaction with 3 steps

1: peracetic acid; sulfuric acid / acetone / 1 h / Reflux

2: tetrahydrofuran / 0 - 20 °C

3: pyridine; hydroxylamine hydrochloride / 1.5 h / Reflux

With pyridine; peracetic acid; sulfuric acid; hydroxylamine hydrochloride; In tetrahydrofuran; acetone;