(2S,5S)-(+)-1,2,5-tricyclohexyl-1-oxophospholane

Base Information

Chemical Name:(2S,5S)-(+)-1,2,5-tricyclohexyl-1-oxophospholane
CAS No.:882354-35-0
Molecular Formula:C₂₂H₃₉OP
Molecular Weight:350.525
Hs Code.:

Synonyms:(2S,5S)-(+)-1,2,5-tricyclohexyl-1-oxophospholane

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Chemical Property of (2S,5S)-(+)-1,2,5-tricyclohexyl-1-oxophospholane

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Technology Process of (2S,5S)-(+)-1,2,5-tricyclohexyl-1-oxophospholane

There total 5 articles about (2S,5S)-(+)-1,2,5-tricyclohexyl-1-oxophospholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 474093-54-4
(2S,5S)-(-)-1-r-oxo-1,2-c,5-triphenyl phospholane

: 882354-35-0
(2S,5S)-(+)-1,2,5-tricyclohexyl-1-oxophospholane

Guidance literature:: With hydrogen; Aliquat 336; rhodium(III) chloride; In dichloromethane; for 48h; under 60004.8 Torr;
DOI:10.1002/ejoc.200500577

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 882354-35-0
(2S,5S)-(+)-1,2,5-tricyclohexyl-1-oxophospholane

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi / tetrahydrofuran / -78 °C

1.2: CuBr*Me₂S / tetrahydrofuran / 0.25 h / -40 - 20 °C

1.3: 88 percent / tetrahydrofuran / -60 - 20 °C

2.1: 90 percent / H₂; Aliquot 336 / RhCl₃*4H₂O / CH₂Cl₂ / 48 h / 60004.8 Torr

With n-butyllithium; hydrogen; Aliquat 336; rhodium(III) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.200500577

Reference yield:

: 591-50-4
iodobenzene

: 882354-35-0
(2S,5S)-(+)-1,2,5-tricyclohexyl-1-oxophospholane

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / 1,3-bis(dphenylphosphanyl)propane; iPrNEt / Pd(OAc)2 / dimethylsulfoxide / 24 h / 100 °C

2: 90 percent / H₂; Aliquot 336 / RhCl₃*4H₂O / CH₂Cl₂ / 48 h / 60004.8 Torr

With 1,3-bis-(diphenylphosphino)propane; hydrogen; Aliquat 336; N-isopropylethylamine; palladium diacetate; rhodium(III) chloride; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/ejoc.200500577