3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine

Base Information

Chemical Name:3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine
CAS No.:1616235-14-3
Molecular Formula:C₂₀H₁₄BrFN₈
Molecular Weight:465.287
Hs Code.:

Synonyms:3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine

There total 9 articles about 3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1616235-69-8
3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

: 4595-60-2
2-bromopyrimidine

: 1616235-14-3
3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine

Guidance literature:: 3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

2-bromopyrimidine; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.666667h;

Reference yield:

: 863605-34-9
4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

: 1616235-14-3
3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 100 °C / Inert atmosphere

2.1: hydrogenchloride; methanol / 1,4-dioxane / 20 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

4.2: 0.67 h / 20 °C

With hydrogenchloride; methanol; potassium phosphate; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 154258-82-9
3-(4-fluorophenyl)-1H-pyrazole

: 1616235-14-3
3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C

3.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 100 °C / Inert atmosphere

4.1: hydrogenchloride; methanol / 1,4-dioxane / 20 °C

5.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

6.2: 0.67 h / 20 °C

With hydrogenchloride; methanol; potassium phosphate; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;