TB-9

Base Information

• Chemical Name: TB-9
• CAS No.: 1415033-91-8
• Molecular Formula: C₅₅H₇₆N₈O₁₂
• Molecular Weight: 1041.25
• Mol file: 1415033-91-8.mol

Synonyms:TB-9

Chemical Property of TB-9

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TB-9

There total 9 articles about TB-9 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H38N4O5 + C30H40N4O8 (1415034-14-8) → TB-9 (1415033-91-8)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃; for 26h;

DOI:10.1021/jm301630s

Reference yield:

tert-butyl (3S,4S)-4-(N,N-dibenzylamino)-3-hydroxy-5-phenylpentanoate (188775-09-9) → TB-9 (1415033-91-8)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogen; palladium on activated charcoal / ethyl acetate / 2 h / 760.05 Torr

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / tetrahydrofuran

3: hydrogen; palladium on activated charcoal / ethyl acetate / 2 h / 760.05 Torr

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 26 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; palladium on activated charcoal; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1021/jm301630s

Reference yield:

C40H47N3O5 → TB-9 (1415033-91-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 26 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm301630s

upstream raw materials:

tert-butyl (3S,4S)-4-(N,N-dibenzylamino)-3-hydroxy-5-phenylpentanoate

L-proline methyl ester monohydrochloride

Nα-Boc-Nα-Me-Phe-D-Pro-OMe

C₁₆H₂₂N₂O₃

Downstream raw materials:

C₄₇H₇₀N₈O₁₀

TB-11