1-methyl-3-[2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propyl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-methyl-3-[2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propyl]-1H-pyrimidine-2,4-dione
CAS No.:1026803-22-4
Molecular Formula:C₂₁H₁₇F₃N₂O₅S
Molecular Weight:466.438
Hs Code.:

Synonyms:1-methyl-3-[2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propyl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-methyl-3-[2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propyl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-methyl-3-[2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propyl]-1H-pyrimidine-2,4-dione

There total 6 articles about 1-methyl-3-[2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propyl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1-methyl-3-[2-hydroxy-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propyl]-1H-pyrimidine-2,4-dione

: 1026803-22-4
1-methyl-3-[2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propyl]-1H-pyrimidine-2,4-dione

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 23 ℃; for 3h;
DOI:10.1021/jm0103920

Reference yield:

: 828-27-3
4-Trifluoromethoxyphenol

: 1026803-22-4
1-methyl-3-[2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propyl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: t-BuOK / pyridine / 1 h / 100 °C

2.1: H₂ / 10percent Pd/C / methanol / 3 h / 3040.2 Torr

3.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

3.2: aq. HCl / 1 h / 70 °C

4.1: KOH / ethanol / 2 h / 80 °C

5.1: 45 percent / K₂CO₃ / dimethylformamide / 16 h / 100 °C

6.1: 86 percent / Dess-Martin periodinane / CH₂Cl₂ / 3 h / 23 °C

With hydrogenchloride; potassium hydroxide; potassium tert-butylate; hydrogen; potassium carbonate; Dess-Martin periodane; sodium nitrite; 10percent Pd/C; In pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0103920

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1026803-22-4
1-methyl-3-[2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propyl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: t-BuOK / pyridine / 1 h / 100 °C

2.1: H₂ / 10percent Pd/C / methanol / 3 h / 3040.2 Torr

3.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

3.2: aq. HCl / 1 h / 70 °C

4.1: KOH / ethanol / 2 h / 80 °C

5.1: 45 percent / K₂CO₃ / dimethylformamide / 16 h / 100 °C

6.1: 86 percent / Dess-Martin periodinane / CH₂Cl₂ / 3 h / 23 °C

With hydrogenchloride; potassium hydroxide; potassium tert-butylate; hydrogen; potassium carbonate; Dess-Martin periodane; sodium nitrite; 10percent Pd/C; In pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0103920