methyl (R)-4-(4-bromophenyl)-2-hydroxy-2-((S)-2-oxocyclohexyl)but-(E)-3-enoate

Base Information

Chemical Name:methyl (R)-4-(4-bromophenyl)-2-hydroxy-2-((S)-2-oxocyclohexyl)but-(E)-3-enoate
CAS No.:1129491-21-9
Molecular Formula:C₁₇H₁₉BrO₄
Molecular Weight:367.239
Hs Code.:

Synonyms:methyl (R)-4-(4-bromophenyl)-2-hydroxy-2-((S)-2-oxocyclohexyl)but-(E)-3-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (R)-4-(4-bromophenyl)-2-hydroxy-2-((S)-2-oxocyclohexyl)but-(E)-3-enoate

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Technology Process of methyl (R)-4-(4-bromophenyl)-2-hydroxy-2-((S)-2-oxocyclohexyl)but-(E)-3-enoate

There total 3 articles about methyl (R)-4-(4-bromophenyl)-2-hydroxy-2-((S)-2-oxocyclohexyl)but-(E)-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 104093-34-7,608128-34-3
methyl (E)-2-oxo-4-(4-bromophenyl)-3-butenoate

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1129491-21-9
methyl (R)-4-(4-bromophenyl)-2-hydroxy-2-((S)-2-oxocyclohexyl)but-(E)-3-enoate

Guidance literature:: With (2S,4R)-4-((tert-butyldiphenylsilyl)oxy)pyrrolidine-2-carboxylic acid; In water; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/adsc.200800248

Reference yield:

: 22780-11-6
1-(2,2,2-trichloroacetoxy)cyclohexene

: 104093-34-7,608128-34-3
methyl (E)-2-oxo-4-(4-bromophenyl)-3-butenoate

: 1129491-21-9
methyl (R)-4-(4-bromophenyl)-2-hydroxy-2-((S)-2-oxocyclohexyl)but-(E)-3-enoate

: (E)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(2-oxocyclohexyl)but-3-enoate

: 1203582-19-7
(E)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(2-oxocyclohexyl)but-3-enoate

Guidance literature:: With methanol; silver trifluoromethanesulfonate; dibutyldimethoxytin; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; at -20 ℃; for 3h; optical yield given as %ee; enantioselective reaction; Molecular sieves 3?; Inert atmosphere;
DOI:10.1002/adsc.200900437

Reference yield:

: 104093-34-7,608128-34-3
methyl (E)-2-oxo-4-(4-bromophenyl)-3-butenoate

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1129491-21-9
methyl (R)-4-(4-bromophenyl)-2-hydroxy-2-((S)-2-oxocyclohexyl)but-(E)-3-enoate

: C₁₇H₁₉BrO₄

Guidance literature:: cyclohexanone; With 4-nitro-phenol; C₂₄H₃₉N₃S; In dichloromethane; at 20 ℃; for 0.166667h;

methyl (E)-2-oxo-4-(4-bromophenyl)-3-butenoate; In dichloromethane; for 48h; Overall yield = 74 %; stereoselective reaction;
DOI:10.1002/cjoc.201400431