ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate

Base Information

• Chemical Name: ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate
• CAS No.: 1316844-47-9
• Molecular Formula: C₁₆H₁₇NO₄
• Molecular Weight: 287.315
• Mol file: 1316844-47-9.mol

Synonyms:ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate

Chemical Property of ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate

There total 3 articles about ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C2H3O2(1-)*C20H19INO2(1+) (1316844-34-4) → ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate (1316844-47-9)

Guidance literature:

With palladium diacetate; acetic acid; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol201665c

Reference yield:

2-methyl-5-phenyl-1H-pyrrole (3042-21-5) → ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate (1316844-47-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 1 - 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: acetic acid / 18 h / 20 °C / Inert atmosphere

3.1: palladium diacetate; acetic acid / 18 h / 20 °C / Inert atmosphere

With palladium diacetate; sodium hydride; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/ol201665c

Reference yield:

ethyl 2-methyl-5-phenyl-1H-pyrrole-1-carboxylate (1316844-22-0) → ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate (1316844-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 18 h / 20 °C / Inert atmosphere

2: palladium diacetate; acetic acid / 18 h / 20 °C / Inert atmosphere

With palladium diacetate; acetic acid;

DOI:10.1021/ol201665c

upstream raw materials:

2-methyl-5-phenyl-1H-pyrrole

C₂H₃O₂^(1-)*C₂₀H₁₉INO₂⁽¹⁺⁾

ethyl 2-methyl-5-phenyl-1H-pyrrole-1-carboxylate