(4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester

Base Information

• Chemical Name: (4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester
• CAS No.: 752251-08-4
• Molecular Formula: C₂₁H₂₃NO₆
• Molecular Weight: 385.417

Synonyms:(4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester

Chemical Property of (4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester

There total 2 articles about (4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

monomethyl monopotassium malonate (38330-80-2) + ((S)-1-Benzyloxymethyl-2-imidazol-1-yl-2-oxo-ethyl)-carbamic acid benzyl ester → (4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester (752251-08-4)

Guidance literature:

monomethyl monopotassium malonate; With magnesium chloride; In tetrahydrofuran; for 5h; Heating;

((S)-1-Benzyloxymethyl-2-imidazol-1-yl-2-oxo-ethyl)-carbamic acid benzyl ester; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1002/anie.200453909

Reference yield:

Z-Ser(Bzl)-OH (20806-43-3) → (4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester (752251-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: MgCl₂

With magnesium chloride;

DOI:10.1055/s-2006-941602

Reference yield: 48.0%

(4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester (752251-08-4) → (3R,4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-hydroxy-pentanoic acid methyl ester (752251-09-5) + (3S,4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-hydroxy-pentanoic acid methyl ester (910252-32-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; diethyl ether; at -60 ℃; for 6h;

DOI:10.1002/anie.200453909

upstream raw materials:

monomethyl monopotassium malonate

Z-Ser(Bzl)-OH

Downstream raw materials:

(3R,4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-hydroxy-pentanoic acid methyl ester

(3S,4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-hydroxy-pentanoic acid methyl ester

(5S,6S)-7-benzyloxy-6-benzyloxycarbonylamino-5-hydroxy-3-oxo-heptanoic acid tert-butyl ester

7-benzyloxy-6-benzyloxycarbonylamino-3,5-dihydroxy-heptanoic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 752251-08-4 (4S)-5-benzyloxy-4-benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send