2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-((4-methylcyclohexyl)amino)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Base Information

Chemical Name:2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-((4-methylcyclohexyl)amino)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide
CAS No.:1396582-18-5
Molecular Formula:C₂₄H₃₀F₄N₄O₃S
Molecular Weight:530.587
Hs Code.:

Synonyms:2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-((4-methylcyclohexyl)amino)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Chemical Property of 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-((4-methylcyclohexyl)amino)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Technology Process of 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-((4-methylcyclohexyl)amino)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

There total 4 articles about 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-((4-methylcyclohexyl)amino)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 824426-35-9
2-[3-fluoro-4-(methylsulfonylamino)phenyl]propionic acid

: C₁₄H₂₀F₃N₃

: 1396582-18-5
2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-((4-methylcyclohexyl)amino)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm300780p

Reference yield:

: C₁₄H₁₆F₃N₃

: 1396582-18-5
2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-((4-methylcyclohexyl)amino)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 12 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300780p

Reference yield:

: 116548-04-0
2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 1396582-18-5
2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-((4-methylcyclohexyl)amino)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / Reflux

2: 16 h / 20 °C

3: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 12 h / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300780p