16-(3-(Trifluoromethyl)phenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf1-alpha

Base Information

Chemical Name:16-(3-(Trifluoromethyl)phenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf1-alpha
CAS No.:73307-37-6
Molecular Formula:C23H29F3O6
Molecular Weight:458.468
Hs Code.:

Synonyms:16-(3-(Trifluoromethyl)phenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf1-alpha;2-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, (1R-(1-alpha(E),2-beta(1E,3S*),3-alpha,5-alpha))-;73307-37-6;LS-74636

Suppliers and Price of 16-(3-(Trifluoromethyl)phenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf1-alpha

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 16-(3-(Trifluoromethyl)phenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf1-alpha

Chemical Property:

Vapor Pressure:1.24E-15mmHg at 25°C
Boiling Point:608°C at 760 mmHg
Flash Point:321.5°C
Density:1.335g/cm³
XLogP3:2.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:11
Exact Mass:458.19162313
Heavy Atom Count:32
Complexity:636

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(C(C(C1O)C=CC(COC2=CC=CC(=C2)C(F)(F)F)O)CC=CCCCC(=O)O)O
Isomeric SMILES:C1C([C@@H](C(C1O)C/C=C/CCCC(=O)O)/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)O

Technology Process of 16-(3-(Trifluoromethyl)phenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf1-alpha

There total 6 articles about 16-(3-(Trifluoromethyl)phenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf1-alpha which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73275-77-1
(5Z,E)-16-<3-(trifluoromethyl)phenoxy>-2,3,17,18,19,20-hexanorprostaglandin F_2α 11,15αβ-bis(tetrahydropyran-2-yl ether)

: 73307-37-6
(E)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E)-(S)-3-hydroxy-4-(3-trifluoromethyl-phenoxy)-but-1-enyl]-cyclopentyl}-hept-2-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 5percent Pd/C / methanol / 25 °C / 760 Torr

2: diethyl ether

3: 100 percent / diisobutylaluminum hydride (DIBAL) / toluene / 0.5 h / -78 °C

4: 95 percent / CHCl₃ / 5 h / 25 °C

5: 1 N aq. HCl / tetrahydrofuran / 1 h / 45 °C

6: 2 N aq. KOH / ethanol / 2 h / 25 °C

With hydrogenchloride; potassium hydroxide; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; chloroform; toluene;
DOI:10.1021/jm00179a011

Reference yield:

: (E)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E)-3-hydroxy-4-(3-trifluoromethyl-phenoxy)-but-1-enyl]-cyclopentyl}-hept-2-enoic acid methyl ester

: 73307-33-2
16-<3-(trifluoromethyl)phenoxy>-17,18,19,20-hexanor-2,2-trans-didehydroprostaglandin F_1α

: 73307-37-6
(E)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E)-(S)-3-hydroxy-4-(3-trifluoromethyl-phenoxy)-but-1-enyl]-cyclopentyl}-hept-2-enoic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 25 ℃; for 2h; Yield given. Yields of byproduct given;
DOI:10.1021/jm00179a011

Reference yield:

: 61903-05-7
16-<3-(trifluoromethyl)phenoxy>-2,3,17,18,19,20-hexanorprost-13-en-1-al 11,15αβ-bis(tetrahydropyran-2-yl ether)

: 73307-37-6
(E)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E)-(S)-3-hydroxy-4-(3-trifluoromethyl-phenoxy)-but-1-enyl]-cyclopentyl}-hept-2-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / CHCl₃ / 5 h / 25 °C

2: 1 N aq. HCl / tetrahydrofuran / 1 h / 45 °C

3: 2 N aq. KOH / ethanol / 2 h / 25 °C

With hydrogenchloride; potassium hydroxide; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jm00179a011