tert-butyl [3,3-bis(ethoxymethyl)bicyclo[2.1.0]pent-1-yl]-N,N-dibenzylaminoacetate

Base Information

Chemical Name:tert-butyl [3,3-bis(ethoxymethyl)bicyclo[2.1.0]pent-1-yl]-N,N-dibenzylaminoacetate
CAS No.:1268616-73-4
Molecular Formula:C₃₁H₄₃NO₄
Molecular Weight:493.687
Hs Code.:

Synonyms:tert-butyl [3,3-bis(ethoxymethyl)bicyclo[2.1.0]pent-1-yl]-N,N-dibenzylaminoacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl [3,3-bis(ethoxymethyl)bicyclo[2.1.0]pent-1-yl]-N,N-dibenzylaminoacetate

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Technology Process of tert-butyl [3,3-bis(ethoxymethyl)bicyclo[2.1.0]pent-1-yl]-N,N-dibenzylaminoacetate

There total 2 articles about tert-butyl [3,3-bis(ethoxymethyl)bicyclo[2.1.0]pent-1-yl]-N,N-dibenzylaminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1268616-67-6
tert-butyl (1-[chloro(p-tolylsulfinyl)methyl]-3,3-bis(ethoxymethyl)cyclobutyl)-N,N-dibenzylaminoacetate

: 1268616-70-1
tert-butyl [4,4-bis(ethoxymethyl)cyclopent-1-enyl]-N,N-dibenzylaminoacetate

: 1268616-73-4
tert-butyl [3,3-bis(ethoxymethyl)bicyclo[2.1.0]pent-1-yl]-N,N-dibenzylaminoacetate

Guidance literature:: With isopropylmagnesium chloride; In diethyl ether; toluene; at -78 - 0 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2010.12.023

Reference yield:

: 938436-17-0
3,3-bis(ethoxymethyl)-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane

: 94226-56-9
tert-butyl 2-(dibenzylamino)ethanoate

: 1268616-70-1
tert-butyl [4,4-bis(ethoxymethyl)cyclopent-1-enyl]-N,N-dibenzylaminoacetate

: 1268616-73-4
tert-butyl [3,3-bis(ethoxymethyl)bicyclo[2.1.0]pent-1-yl]-N,N-dibenzylaminoacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran

1.2: 1 h / -45 °C

2.1: isopropylmagnesium chloride / diethyl ether; toluene / 2 h / -78 - 0 °C / Inert atmosphere

With isopropylmagnesium chloride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1016/j.tet.2010.12.023