Tert-butyl N-[(2R)-1-iodo-3-phenylpropan-2-YL]carbamate

Base Information

Chemical Name:Tert-butyl N-[(2R)-1-iodo-3-phenylpropan-2-YL]carbamate
CAS No.:293305-69-8
Molecular Formula:C₁₄H₂₀INO₂
Molecular Weight:361.223
Hs Code.:
DSSTox Substance ID:DTXSID30565798
Nikkaji Number:J1.413.142F
Wikidata:Q82451072
Mol file:293305-69-8.mol

Synonyms:293305-69-8;(R)-N-Boc-|A-(iodomethyl)benzeneethanamine;TERT-BUTYL N-[(2R)-1-IODO-3-PHENYLPROPAN-2-YL]CARBAMATE;N-[(1R)-1-(Iodomethyl)-2-phenylethyl]carbamic Acid 1,1-Dimethylethyl Ester;(R)-N-Boc-alpha-(iodomethyl)benzeneethanamine;DTXSID30565798;(R)-N-Boc-?-(iodomethyl)benzeneethanamine;J-017475;(R)-tert-Butyl (1-iodo-3-phenylpropan-2-yl)carbamate;tert-Butyl [(2R)-1-iodo-3-phenylpropan-2-yl]carbamate;TERT-BUTYLN-[(2R)-1-IODO-3-PHENYLPROPAN-2-YL]CARBAMATE;194096-74-7

Suppliers and Price of Tert-butyl N-[(2R)-1-iodo-3-phenylpropan-2-YL]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Tert-butyl N-[(2R)-1-iodo-3-phenylpropan-2-YL]carbamate

Chemical Property:

Melting Point:121-122 °C
Boiling Point:405.0±45.0 °C(Predicted)
PKA:11.81±0.46(Predicted)
Density:1.428±0.06 g/cm3(Predicted)
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:361.05388
Heavy Atom Count:18
Complexity:257

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC=CC=C1)CI
Isomeric SMILES:CC(C)(C)OC(=O)N[C@H](CC1=CC=CC=C1)CI

Technology Process of Tert-butyl N-[(2R)-1-iodo-3-phenylpropan-2-YL]carbamate

There total 3 articles about Tert-butyl N-[(2R)-1-iodo-3-phenylpropan-2-YL]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 106454-69-7
N-tert-butoxycarbonyl-D-Phenylalaninol

: 293305-69-8
(R)-2-(N-t-butoxycarbonylamino)-3-phenyl-1-iodopropane

Guidance literature:: With 1H-imidazole; triphenylphosphine polystyryl-supported; iodine; In dichloromethane; for 2h; Heating;
DOI:10.1021/jo000242h

Reference yield:

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 293305-69-8
(R)-2-(N-t-butoxycarbonylamino)-3-phenyl-1-iodopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / CHCl₃ / 0 - 20 °C

2: 88 percent / iodine; triphenylphosphine polystyryl-supported; imidazole / CH₂Cl₂ / 2 h / Heating

With 1H-imidazole; triphenylphosphine polystyryl-supported; iodine; In dichloromethane; chloroform; 1: Substitution / 2: Substitution;
DOI:10.1021/jo000242h

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 293305-69-8
(R)-2-(N-t-butoxycarbonylamino)-3-phenyl-1-iodopropane

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / lithium borohydride; trimethylsilyl chloride / tetrahydrofuran / 0.25 h / 20 °C

2: 95 percent / CHCl₃ / 0 - 20 °C

3: 88 percent / iodine; triphenylphosphine polystyryl-supported; imidazole / CH₂Cl₂ / 2 h / Heating

With 1H-imidazole; lithium borohydride; chloro-trimethyl-silane; triphenylphosphine polystyryl-supported; iodine; In tetrahydrofuran; dichloromethane; chloroform; 1: Reduction / 2: Substitution / 3: Substitution;
DOI:10.1021/jo000242h