morpholine-4-carboxylic acid {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-amide trifluoroacetate

Base Information

Chemical Name:morpholine-4-carboxylic acid {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-amide trifluoroacetate
CAS No.:943776-92-9
Molecular Formula:C₂HF₃O₂*C₃₄H₃₂BrN₇O₄
Molecular Weight:796.601
Hs Code.:

morpholine-4-carboxylic acid {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-amide trifluoroacetate

Synonyms:morpholine-4-carboxylic acid {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-amide trifluoroacetate

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Chemical Property of morpholine-4-carboxylic acid {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-amide trifluoroacetate

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Technology Process of morpholine-4-carboxylic acid {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-amide trifluoroacetate

There total 12 articles about morpholine-4-carboxylic acid {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-amide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 110-91-8,99108-56-2
morpholine

: 943776-95-2
{4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-carbamic acid 2,2,2-trichloro-ethyl ester

: 76-05-1
trifluoroacetic acid

: 943776-92-9
morpholine-4-carboxylic acid {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-amide trifluoroacetate

Guidance literature:: morpholine; {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-carbamic acid 2,2,2-trichloro-ethyl ester; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 65 ℃; for 1h;

trifluoroacetic acid;

Reference yield:

: 563-80-4
3-methyl-butan-2-one

: 943776-92-9
morpholine-4-carboxylic acid {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-amide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium / diethyl ether / 0 - 20 °C

2.1: water / 0.17 h / 20 °C

2.2: 2 h / Heating / reflux

2.3: pH 4

3.1: tetrabutylammomium bromide; phosphorus pentoxide / toluene / 5 h / Heating / reflux

4.1: ammonia / ethanol / 20 h / 130 °C

5.1: toluene / 3 h / Heating / reflux

6.1: acetic acid / 0.25 h / 130 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 65 °C

With tetrabutylammomium bromide; ammonia; sodium; phosphorus pentoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; diethyl ether; ethanol; water; acetic acid; toluene;

Reference yield:

: 943771-00-4
2-bromo-6-isopropyl-nicotinonitrile

: 943776-92-9
morpholine-4-carboxylic acid {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenoxy]-phenyl}-amide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / ethanol / 20 h / 130 °C

2: toluene / 3 h / Heating / reflux

3: acetic acid / 0.25 h / 130 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 65 °C

With ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethanol; acetic acid; toluene;