3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride

Base Information

Chemical Name:3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride
CAS No.:1023-85-4
Molecular Formula:C₁₄H₁₉N₃O*ClH
Molecular Weight:281.785
Hs Code.:
European Community (EC) Number:213-825-8
NSC Number:118101
DSSTox Substance ID:DTXSID10144883
Mol file:1023-85-4.mol

Synonyms:1023-85-4;3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride;NSC 118101;EINECS 213-825-8;3-methyl-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride;1,3,8-Triazaspiro(4.5)decan-4-one, 3-methyl-1-phenyl-, hydrochloride;3-Methyl-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one hydrochloride;3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;hydrochloride;3-Methyl-1-phenyl-1,3,8-triazaspiro(4,5)decan-4-one hydrochloride;1,3,8-Triazaspiro[4,5]decan-4-one, 3-methyl-1-phenyl-, hydrochloride;1,3,8-Triazaspiro[4.5]decan-4-one, 3-methyl-1-phenyl-, hydrochloride;SCHEMBL9485290;DTXSID10144883;NSC118101;NSC-118101;LS-154811;A927654;3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-onehydrochloride;3-Methyl-1-phenyl-1,8-triazaspiro[4.5]decan-4-one hydrochloride;1,3,8-Triazaspiro(4.5)decan-4-one, 3-methyl-1-phenyl-, monohydrochloride;1,8-Triazaspiro[4.5]decan-4-one, 3-methyl-1-phenyl-, hydrochloride

Suppliers and Price of 3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-onehydrochloride 95+%
1g
$ 842.00

Chemenu
3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-onehydrochloride 95%
1g
$ 795.00

American Custom Chemicals Corporation
3-METHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE HYDROCHLORIDE 95.00%
5MG
$ 502.22

Alichem
3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-onehydrochloride
1g
$ 690.84

Total 11 raw suppliers

Chemical Property of 3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride

Chemical Property:

Vapor Pressure:3.82E-08mmHg at 25°C
Boiling Point:445.9°Cat760mmHg
Flash Point:223.4°C
PSA：35.58000
Density:g/cm³
LogP:2.17840
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:281.1294900
Heavy Atom Count:19
Complexity:319

Purity/Quality:

97% ^*data from raw suppliers

3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-onehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CN(C2(C1=O)CCNCC2)C3=CC=CC=C3.Cl

Technology Process of 3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride

There total 2 articles about 3-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 209530-76-7
tert-butyl-3-methyl-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

: 1023-85-4,1047655-39-9
3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride

Guidance literature:: With acetyl chloride; In methanol; for 2h;

Reference yield:

: 138091-52-8
8-(tert-Butoxycarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

: 1023-85-4,1047655-39-9
3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 0.25 h / 20 °C

2.1: acetyl chloride / methanol / 2 h

With sodium hydride; acetyl chloride; In methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1023-85-4,1047655-39-9
3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride

: 5-ethyl-2-fluoro-N-((2R,3S)-3-methoxy-1-(3-methyl-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-yl)-1-oxobutan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h

2: hydrogenchloride / 1,4-dioxane / 0.5 h

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane;