(2R,4S,5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide

Base Information

• Chemical Name: (2R,4S,5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide
• CAS No.: 132094-41-8
• Molecular Formula: C₂₈H₄₈N₄O₅S
• Molecular Weight: 552.779

Synonyms:(2R,4S,5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide

Chemical Property of (2R,4S,5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide

Chemical Property:

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Technology Process of (2R,4S,5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide

There total 1 articles about (2R,4S,5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (2R,4S,5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide (132094-41-8)

Guidance literature:

Reference yield:

2(R)-benzyl[-3-(morpholinocarbonyl)propionic acid + (2R,4S,5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide (132094-41-8) + diethyl cyanophosphonate (2942-58-7) → (2R,4S,5S)-5-{N-[2(R)-benzyl-3-(morpholinocarbonyl)propionyl]-3-(-4-thiazolyl)-L-alanyl}amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide (132094-07-6)

Guidance literature:

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; benzene;

Reference yield:

(2R,4S,5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide (132094-41-8) + 2-(R)-(4-methoxybenzyl)-3-morpholinocarbonyl propionic acid (125075-98-1) → (2R,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-{N-[2(R)-(4-methoxybenzyl)-3-(morpholinocarbonyl)propionyl]-3-(4-thiazolyl)-L-alanyl}amino-2-methylhexanamide (132094-08-7)

Guidance literature:

Downstream raw materials:

(2R,4S,5S)-5-{N-[2(R)-benzyl-3-(morpholinocarbonyl)propionyl]-3-(-4-thiazolyl)-L-alanyl}amino-N-butyl-6-cyclohexyl-4-hydroxy-2-methylhexanamide

(2R,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-{N-[2(R)-(4-methoxybenzyl)-3-(morpholinocarbonyl)propionyl]-3-(4-thiazolyl)-L-alanyl}amino-2-methylhexanamide

(2R,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-{N-[2(R)-(4-methoxybenzyl)-3-(N-benzyl-N-methylaminocarbonyl)propionyl]-3-(4-thiazolyl)-L-alanyl}amino-2-methylhexanamide

(2R,4S,5S)-N-Butyl-6-cyclohexyl-4-hydroxy-5-{N-[2(R)-(4-methoxybenzyl)-3-(piperidinocarbonyl)propionyl]-3-(4-thiazolyl)-L-alanyl}amino-2-methylhexanamide

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