4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidine

Base Information

Chemical Name:4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidine
CAS No.:1428253-42-2
Molecular Formula:C₂₀H₂₇FN₄
Molecular Weight:342.46
Hs Code.:

Synonyms:4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidine

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Chemical Property of 4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidine

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Technology Process of 4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidine

There total 7 articles about 4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1428252-97-4
4-[1-(2-azetidin-1-ylethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid tert-butyl ester

: 1428253-42-2
4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 4h;

Reference yield:

: 1428252-94-1
tert-butyl 4-(4-bromo-1H-imidazol-2-yl)piperidine-1-carboxylate

: 1428253-42-2
4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 1.5 h

1.2: 4 h

1.3: 0.33 h / 20 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: N,N-dimethyl-formamide / 50 °C

4.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 50 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C

With hydrogenchloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; triethylamine; potassium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1226803-00-4
tert-butyl 4-(4-bromo-1-(2-hydroxyethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

: 1428253-42-2
4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: N,N-dimethyl-formamide / 50 °C

3: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 50 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C

With hydrogenchloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;