Technology Process of tert-butyl (7-((2,6-dichlorobenzyl)oxy)-2-oxo-1,2,3,4-tetrahydroquinolin-5-yl)carbamate
There total 18 articles about tert-butyl (7-((2,6-dichlorobenzyl)oxy)-2-oxo-1,2,3,4-tetrahydroquinolin-5-yl)carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 0 °C / Inert atmosphere
2: palladium 10% on activated carbon; ammonium acetate; hydrogen; magnesium / methanol / 24 h / 2068.65 - 2585.81 Torr
3: boron tribromide / dichloromethane / Inert atmosphere
4: tetrahydrofuran / Inert atmosphere
5: potassium carbonate / acetonitrile / 2 h / 60 °C
With
palladium 10% on activated carbon; ammonium acetate; hydrogen; boron tribromide; potassium carbonate; magnesium; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1002/chem.201102732
- Guidance literature:
-
Multi-step reaction with 11 steps
1: potassium carbonate / acetone / 22 h / Reflux
2: water; sodium hydroxide / 1,4-dioxane; ethanol / 0.58 h / 20 °C
3: thionyl chloride / chloroform / 1 h / Reflux
4: tetrahydrofuran; diethyl ether / 1.17 h / 0 - 20 °C / Inert atmosphere
5: silver benzoate; triethylamine / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere; Darkness
6: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 0.58 h / 517.16 Torr
7: silver(l) oxide / chloroform; dimethyl sulfoxide / 72 h / Darkness; Reflux
8: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 48 h / 2068.65 - 2585.81 Torr
9: boron tribromide / dichloromethane / Inert atmosphere
10: tetrahydrofuran / Inert atmosphere
11: potassium carbonate / acetonitrile / 2 h / 60 °C
With
thionyl chloride; palladium 10% on activated carbon; water; hydrogen; silver benzoate; boron tribromide; potassium carbonate; triethylamine; sodium hydroxide; silver(l) oxide;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; acetone; acetonitrile;
DOI:10.1002/chem.201102732
