[2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine

Base Information

• Chemical Name: [2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine
• CAS No.: 454219-02-4
• Molecular Formula: C₂₃H₃₄ClN₃O₃Si
• Molecular Weight: 464.08

Synonyms:[2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine

Chemical Property of [2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine

Chemical Property:

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Technology Process of [2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine

There total 1 articles about [2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine (82408-64-8) + (R)-toluene-4-sulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl ester (364080-73-9) → [2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine (454219-02-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 48h;

DOI:10.1016/j.bmcl.2004.03.089

Reference yield: 93.0%

[2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine (454219-02-4) → 4-{2(R)-[2-(tert-butyl-dimethyl-silanyloxy)-2-pyridin-3-yl-ethylamino]-2-methyl-propyl}-phenylamine (454219-03-5)

Guidance literature:

With palladium on activated charcoal; ammonium formate; In methanol;

DOI:10.1016/j.bmcl.2004.03.089

Reference yield:

[2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine (454219-02-4) → 4-{2(R)-[2-(tert-butyl-dimethyl-silanyloxy)-2-pyridin-3-yl-ethyl]amino]-2-methyl-propyl}-phenylamine + 4-{2(R)-[2-(tert-Butyl-dimethyl-silanyloxy)-2-pyridin-3-yl-ethylamino]-2-methyl-propyl}-phenylamine

Guidance literature:

With ammonium formate; palladium; In methanol;

upstream raw materials:

N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine

(R)-toluene-4-sulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl ester

Downstream raw materials:

4-{2(R)-[2-(tert-butyl-dimethyl-silanyloxy)-2-pyridin-3-yl-ethylamino]-2-methyl-propyl}-phenylamine

N'-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]-2-methylpropyl]phenyl]-N,N-dimethyl-sulfamide

N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]-2-methylpropyl]phenyl]-N'-(2-methoxyethyl)-sulfamide

N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]-2-methylpropyl]phenyl]-N'-phenyl-sulfamide

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