Technology Process of (3S,6E,8E,11E)-14-tert-butyldiphenylsilyloxy-3,9,11-trimethyltetradeca-6,8,11-trienoic acid
There total 13 articles about (3S,6E,8E,11E)-14-tert-butyldiphenylsilyloxy-3,9,11-trimethyltetradeca-6,8,11-trienoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene;
In
tert-butyl alcohol;
for 0.5h;
DOI:10.1039/b111146a
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: PPh3; pyridine / CH2Cl2 / 0.17 h / 0 °C
1.2: 93 percent / CH2Cl2 / 2 h / 0 °C
2.1: 88 percent / n-BuLi / tetrahydrofuran; hexane / 4.5 h / -78 - 20 °C
3.1: tetrahydrofuran / 3 h / Heating
4.1: 17.86 g / aq. NaOH / Pd(PPh3)4 / benzene / 10 h / Heating
5.1: 60 percent / aq. AcOH / tetrahydrofuran / 40 h / 20 °C
6.1: 82 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 2.5 h / -78 - 0 °C
7.1: 99 percent / aq. NaClO2; NaH2PO4*2H2O; 2-methyl-2-butene / 2-methyl-propan-2-ol / 0.5 h
With
pyridine; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; hexane; dichloromethane; tert-butyl alcohol; benzene;
4.1: Suzuki reaction / 6.1: Swern oxidation;
DOI:10.1039/b111146a
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 99 percent / imidazole / dimethylformamide / 0.5 h / 0 °C
2.1: dichlorobis(η5-pentadienyl)zirconium / CH2Cl2; toluene / 5.5 h / 20 °C
2.2: 88 percent / I2 / CH2Cl2; toluene; tetrahydrofuran / 1 h / 0 °C
3.1: 17.86 g / aq. NaOH / Pd(PPh3)4 / benzene / 10 h / Heating
4.1: 60 percent / aq. AcOH / tetrahydrofuran / 40 h / 20 °C
5.1: 82 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 2.5 h / -78 - 0 °C
6.1: 99 percent / aq. NaClO2; NaH2PO4*2H2O; 2-methyl-2-butene / 2-methyl-propan-2-ol / 0.5 h
With
1H-imidazole; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; acetic acid; dimethyl sulfoxide; triethylamine;
tetrakis(triphenylphosphine) palladium(0); zirconocene dichloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;
3.1: Suzuki reaction / 5.1: Swern oxidation;
DOI:10.1039/b111146a
