(4-{5-[1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)acetonitrile

Base Information

Chemical Name:(4-{5-[1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)acetonitrile
CAS No.:1388214-12-7
Molecular Formula:C₂₁H₁₅F₃N₆O₂
Molecular Weight:440.384
Hs Code.:

Synonyms:(4-{5-[1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)acetonitrile

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Chemical Property of (4-{5-[1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)acetonitrile

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Technology Process of (4-{5-[1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)acetonitrile

There total 4 articles about (4-{5-[1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1388210-98-7
2-(4-{5-[1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)acetamide

: 1388214-12-7
(4-{5-[1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)acetonitrile

Guidance literature:: With pyridine; trichlorophosphate; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

: ethyl 1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazole-4-carboxylate

: 1388214-12-7
(4-{5-[1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol; water / 1 h / Reflux

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2.2: 14 h / 80 °C / Inert atmosphere

3.1: pyridine; trichlorophosphate / 3 h / 20 °C / Cooling with ice

With pyridine; 1,1'-carbonyldiimidazole; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazole-4-carboxylic acid

: 1388214-12-7
(4-{5-[1-methyl-5-({[5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

1.2: 14 h / 80 °C / Inert atmosphere

2.1: pyridine; trichlorophosphate / 3 h / 20 °C / Cooling with ice

With pyridine; 1,1'-carbonyldiimidazole; trichlorophosphate; In N,N-dimethyl-formamide;