N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide

Base Information

Chemical Name:N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide
CAS No.:1185282-03-4
Molecular Formula:C₂₄H₂₁FN₄O₂
Molecular Weight:416.455
Hs Code.:

Synonyms:N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide

Suppliers and Price of N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
APP-FUBINACARM
50mg
$ 495.00

Cayman Chemical
APP-FUBINACA ≥98%
50mg
$ 1495.00

Cayman Chemical
APP-FUBINACA ≥98%
1mg
$ 65.00

Cayman Chemical
APP-FUBINACA ≥98%
5mg
$ 260.00

AK Scientific
App-fubinaca
50mg
$ 2118.00

AK Scientific
App-fubinaca
1mg
$ 187.00

Total 1 raw suppliers

Chemical Property of N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

APP-FUBINACARM ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses APP-FUBINACA RM is an analog of AB-FUBINACA which is an indazole derivative developed as a CB1 receptor modulator used in the treatment of CB1-mediated diseases. Synthetic cannabinoids

Technology Process of N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide

There total 4 articles about N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 5241-58-7
L-Phenylalanine amide

: 50264-63-6
1-(4-fluoro-benzyl)-1H-indazole-3-carboxylic acid

: 1185282-03-4
N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 18h;

Reference yield:

: 43120-28-1
methyl 1H-indazole-3-carboxylate

: 1185282-03-4
N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 25 °C / Cooling with ice

1.2: 5 h / 0 - 20 °C

2.1: sodium hydroxide / methanol / 12 h / 18 - 25 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 18 - 25 °C

With potassium tert-butylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1185282-03-4
N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 25 °C / Cooling with ice

1.2: 5 h / 0 - 20 °C

2.1: sodium hydroxide / methanol / 12 h / 18 - 25 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 18 - 25 °C

With potassium tert-butylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;