2-(3,5-dichloro-4-hydroxyphenyl)-2-oxoethanoic acid

Base Information

Chemical Name:2-(3,5-dichloro-4-hydroxyphenyl)-2-oxoethanoic acid
CAS No.:400778-04-3
Molecular Formula:C₈H₄Cl₂O₄
Molecular Weight:235.023
Hs Code.:

Synonyms:2-(3,5-dichloro-4-hydroxyphenyl)-2-oxoethanoic acid

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Chemical Property of 2-(3,5-dichloro-4-hydroxyphenyl)-2-oxoethanoic acid

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Technology Process of 2-(3,5-dichloro-4-hydroxyphenyl)-2-oxoethanoic acid

There total 4 articles about 2-(3,5-dichloro-4-hydroxyphenyl)-2-oxoethanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 586413-77-6
(3,5-dichloro-4-hydroxy-phenyl)-oxo-acetic acid methyl ester

: 400778-04-3
2-(3,5-dichloro-4-hydroxyphenyl)-2-oxoethanoic acid

Guidance literature:: With sodium hydroxide; In methanol; at 0 - 22 ℃; for 1h;
DOI:10.1021/ja030249r

Reference yield:

: 87-65-0
2,6-Dichlorophenol

: 400778-04-3
2-(3,5-dichloro-4-hydroxyphenyl)-2-oxoethanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: NIS / 2 h / 22 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: 44 mg / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.1: aq. NaOH / methanol / 1 h / 0 - 22 °C

With sodium hydroxide; N-iodo-succinimide; n-butyllithium; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/ja030249r

Reference yield:

: 34074-22-1
2,6-dichloro-4-iodophenol

: 400778-04-3
2-(3,5-dichloro-4-hydroxyphenyl)-2-oxoethanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 44 mg / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.1: aq. NaOH / methanol / 1 h / 0 - 22 °C

With sodium hydroxide; n-butyllithium; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/ja030249r