8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-pyridin-3-yl)-propyl]-octanoic acid methyl ester

Base Information

Chemical Name:8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-pyridin-3-yl)-propyl]-octanoic acid methyl ester
CAS No.:1026811-79-9
Molecular Formula:C₂₄H₃₃ClN₂O₄S
Molecular Weight:481.056
Hs Code.:

Synonyms:8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-pyridin-3-yl)-propyl]-octanoic acid methyl ester

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Chemical Property of 8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-pyridin-3-yl)-propyl]-octanoic acid methyl ester

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Technology Process of 8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-pyridin-3-yl)-propyl]-octanoic acid methyl ester

There total 12 articles about 8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-pyridin-3-yl)-propyl]-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 144385-73-9
8-(4-Chloro-benzenesulfonylamino)-4-[(Z)-3-(4-methyl-pyridin-3-yl)-allyl]-octanoic acid methyl ester

: 1026811-79-9
8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-pyridin-3-yl)-propyl]-octanoic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 68h; under 760 Torr;
DOI:10.1021/jm00101a015

Reference yield:

: 144385-72-8
5-(4-Amino-butyl)-oxepan-2-one

: 1026811-79-9
8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-pyridin-3-yl)-propyl]-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h

2: 1N aq. NaOH / methanol / 18 h

3: SOCl₂ / 2.5 h

4: (COCl)2, Et₃N / CH₂Cl₂ / 0.25 h / -60 °C

5: 1.) t-BuOK / 1.) THF, RT, 1 h, 2.) THF, 2 h

6: 82 percent / H₂ / 10percent Pd/C / ethyl acetate / 68 h / 760 Torr

With dmap; sodium hydroxide; thionyl chloride; oxalyl dichloride; potassium tert-butylate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00101a015

Reference yield:

: 134163-31-8
4-(4-hydroxybutyl)-ε-caprolactone

: 1026811-79-9
8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-pyridin-3-yl)-propyl]-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 1 h

2: 92 percent / NaN₃ / dimethylformamide / 18 h

3: 100 percent / Ph₃P, H₂O / tetrahydrofuran / 18 h / Ambient temperature

4: Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h

5: 1N aq. NaOH / methanol / 18 h

6: SOCl₂ / 2.5 h

7: (COCl)2, Et₃N / CH₂Cl₂ / 0.25 h / -60 °C

8: 1.) t-BuOK / 1.) THF, RT, 1 h, 2.) THF, 2 h

9: 82 percent / H₂ / 10percent Pd/C / ethyl acetate / 68 h / 760 Torr

With dmap; sodium hydroxide; thionyl chloride; sodium azide; oxalyl dichloride; potassium tert-butylate; water; hydrogen; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00101a015