1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(2-phenylpyrimidin-4-yl)urea

Base Information

Chemical Name:1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(2-phenylpyrimidin-4-yl)urea
CAS No.:1300056-91-0
Molecular Formula:C₂₆H₃₀N₆O
Molecular Weight:442.564
Hs Code.:

Synonyms:1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(2-phenylpyrimidin-4-yl)urea

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Chemical Property of 1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(2-phenylpyrimidin-4-yl)urea

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Technology Process of 1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(2-phenylpyrimidin-4-yl)urea

There total 10 articles about 1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(2-phenylpyrimidin-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33630-25-0
4-amino-2-phenylpyrimidine

: C₁₆H₂₁N₃O

: 1300056-91-0
1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(2-phenylpyrimidin-4-yl)urea

Guidance literature:: In toluene; at 100 ℃; for 2h; Sealed tube;
DOI:10.1016/j.bmc.2011.02.036

Reference yield:

: 1300056-78-3
methyl 1-[3-(tert-butyldimethylsilyloxy)propyl]-1H-indole-3-carboxylate

: 1300056-91-0
1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(2-phenylpyrimidin-4-yl)urea

Guidance literature:: Multi-step reaction with 8 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 5 h / 0 °C / Inert atmosphere

3: tetrahydrofuran; dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

4: sodium hydroxide / methanol; water / 36 h / 60 °C

5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C / Inert atmosphere

6: sodium azide / tetrahydrofuran; water / 4 h / 0 °C

7: toluene / 0.75 h / 100 °C / Sealed tube

8: toluene / 2 h / 100 °C / Sealed tube

With 2,6-dimethylpyridine; sodium azide; oxalyl dichloride; tetrabutyl ammonium fluoride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 7: Curtius rearrangement;
DOI:10.1016/j.bmc.2011.02.036

Reference yield:

: methyl 1-(3-hydroxypropyl)-1H-indole-3-carboxylate

: 1300056-91-0
1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(2-phenylpyrimidin-4-yl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: 2,6-dimethylpyridine / dichloromethane / 5 h / 0 °C / Inert atmosphere

2: tetrahydrofuran; dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

3: sodium hydroxide / methanol; water / 36 h / 60 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C / Inert atmosphere

5: sodium azide / tetrahydrofuran; water / 4 h / 0 °C

6: toluene / 0.75 h / 100 °C / Sealed tube

7: toluene / 2 h / 100 °C / Sealed tube

With 2,6-dimethylpyridine; sodium azide; oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 6: Curtius rearrangement;
DOI:10.1016/j.bmc.2011.02.036