{5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazol-4-yl}-(4-methoxy-phenyl)-methanol

Base Information

Chemical Name:{5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazol-4-yl}-(4-methoxy-phenyl)-methanol
CAS No.:197151-44-3
Molecular Formula:C₃₀H₃₄N₂O₇S
Molecular Weight:566.675
Hs Code.:

Synonyms:{5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazol-4-yl}-(4-methoxy-phenyl)-methanol

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Chemical Property of {5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazol-4-yl}-(4-methoxy-phenyl)-methanol

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Technology Process of {5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazol-4-yl}-(4-methoxy-phenyl)-methanol

There total 1 articles about {5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazol-4-yl}-(4-methoxy-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171780-60-2
(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-(3-methyl-2-phenylsulfanyl-3H-imidazol-4-yl)-methanol

: 197151-44-3
{5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazol-4-yl}-(4-methoxy-phenyl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, RT, 1 h

2: 59 percent / N-bromosuccinimide / tetrahydrofuran / 3 h / -30 °C

3: 1.) t-BuLi / 1.) pentane, ether, 23 deg C, 2 min, 2.) pentane, ether, -78 deg C, 1 h

With N-Bromosuccinimide; tert.-butyl lithium; sodium hydride; In tetrahydrofuran;
DOI:10.1248/cpb.45.1393

Reference yield: 99.1%

: 108-24-7
acetic anhydride

: 197151-44-3
{5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazol-4-yl}-(4-methoxy-phenyl)-methanol

: 171780-64-6
Acetic acid 6,7-dimethoxy-9-(4-methoxy-phenyl)-3-methyl-2-phenylsulfanyl-3H-naphtho[2,3-d]imidazol-5-yl ester

Guidance literature:: With PPA; at 0 ℃;
DOI:10.1016/0040-4039(95)01770-I

Reference yield:

: 197151-44-3
{5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazol-4-yl}-(4-methoxy-phenyl)-methanol

: 124535-78-0
2-Hydroxy-6,7-dimethoxy-4-(4-methoxy-phenyl)-1-methyl-1H-naphtho[2,3-d]imidazole-5,8-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / polyphosphoric acid / 0.08 h / 0 °C

2: 100 percent / NaBH₄, NiCl₂*6H₂O / methanol; tetrahydrofuran / 1 h / 0 °C

3: aq. Na₂CO₃ / methanol / 1 h / Ambient temperature

4: imidazole / dimethylformamide / 12 h / 60 °C

5: 1.) LDA, 2.) (PhCH₂OCOO)2 / 1.) n-hexane, THF, -78 deg C, 2 h, 2.) n-hexane, THF, RT, 1 h

6: tetrabutylammonium fluoride / tetrahydrofuran / 0.08 h / Ambient temperature

7: salcomine, O₂ / acetonitrile / 2 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; PPA; dibenzyl peroxydicarbonate; salcomine; tetrabutyl ammonium fluoride; oxygen; sodium carbonate; nickel dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.45.1393