(4aR^*,5S^*,6S^*,7S^*,8aS^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-5-hydroxymethyl-6-methoxy-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone

Base Information

• Chemical Name: (4aR^*,5S^*,6S^*,7S^*,8aS^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-5-hydroxymethyl-6-methoxy-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone
• CAS No.: 109961-00-4
• Molecular Formula: C₂₆H₃₉NO₅
• Molecular Weight: 445.599

Synonyms:(4aR^*,5S^*,6S^*,7S^*,8aS^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-5-hydroxymethyl-6-methoxy-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone

Chemical Property of (4aR^*,5S^*,6S^*,7S^*,8aS^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-5-hydroxymethyl-6-methoxy-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aR^*,5S^*,6S^*,7S^*,8aS^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-5-hydroxymethyl-6-methoxy-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone

There total 5 articles about (4aR^*,5S^*,6S^*,7S^*,8aS^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-5-hydroxymethyl-6-methoxy-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4aR*,5S*,6S*,7S*,8aS*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-6-methoxy-5-((methoxymethoxy)methyl)-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone (96648-94-1) → (4aR*,5S*,6S*,7S*,8aS*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-5-hydroxymethyl-6-methoxy-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone (109961-00-4)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 45 ℃; for 18h;

DOI:10.1021/ja00254a036

Reference yield:

(4aR*,5S*,6S*,7S*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-3,4,4a,5,6,7-hexahydro-6-hydroxy-5-((methoxymethoxy)methyl)-1(2H)-isoquinolone (96648-92-9) → (4aR*,5S*,6S*,7S*,8aS*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-5-hydroxymethyl-6-methoxy-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone (109961-00-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / Ag₂O, CaSO₄ / 96 h / Ambient temperature

2: 90 percent / H₂ / 20 percent Pd(OH)2/C / methanol / 24 h / 93086.7 Torr

3: 87 percent / p-toluenesulfonic acid / methanol / 18 h / 45 °C

With calcium sulfate; hydrogen; toluene-4-sulfonic acid; silver(l) oxide; palladium dihydroxide; In methanol;

DOI:10.1021/ja00254a036

Reference yield:

(4aR*,5S*,6S*,7R*)-2-benzyl-3,4,4a,5,6,7-hexahydro-5-((methoxymethoxy)methyl)-6,7-oxy-1(2H)-isoquinolone (96648-91-8) → (4aR*,5S*,6S*,7S*,8aS*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-5-hydroxymethyl-6-methoxy-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone (109961-00-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / lithium 2-ethylhexanoate / 1,2-dimethoxy-ethane / 16 h / Heating

2: 98 percent / Ag₂O, CaSO₄ / 96 h / Ambient temperature

3: 90 percent / H₂ / 20 percent Pd(OH)2/C / methanol / 24 h / 93086.7 Torr

4: 87 percent / p-toluenesulfonic acid / methanol / 18 h / 45 °C

With calcium sulfate; hydrogen; lithium 2-ethylhexanoate; toluene-4-sulfonic acid; silver(l) oxide; palladium dihydroxide; In methanol; 1,2-dimethoxyethane;

DOI:10.1021/ja00254a036

upstream raw materials:

(4aR^*,5S^*,6S^*,7S^*,8aS^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-6-methoxy-5-((methoxymethoxy)methyl)-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone

(4aR^*,5S^*,6S^*,7R^*)-2-benzyl-3,4,4a,5,6,7-hexahydro-5-((methoxymethoxy)methyl)-6,7-oxy-1(2H)-isoquinolone

(4aR^*,5S^*,6S^*,7S^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-3,4,4a,5,6,7-hexahydro-6-hydroxy-5-((methoxymethoxy)methyl)-1(2H)-isoquinolone

(4aR^*,5S^*)-2-benzyl-5-((methoxymethoxy)methyl)-3,4,4a,5-tetrahydro-1(2H)-isoquinolone

Downstream raw materials:

2,3-seco-2,3-dihydroreserpine

(4aR^*,5S^*,6S^*,7S^*,8aR^*)-2-benzyl-6-methoxy-5-(methoxycarbonyl)-7-((3,4,5-trimethoxybenzoyl)oxy)perhydroisoquinoline

(4aR^*,5S^*,6S^*,7S^*,8aS^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-6-methoxy-5-(methoxycarbonyl)-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-isoquinolone

(4aR^*,5S^*,6S^*,7S^*,8aS^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-6-methoxy-5-(methoxycarbonyl)perhydroisoquinoline

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