1-[5'-(3''-bromo-propan-1''-yl)-2'-furanyl]-2-(2'''-oxo-but-3'''-yn-1'''-yl)benzene

Base Information

Chemical Name:1-[5'-(3''-bromo-propan-1''-yl)-2'-furanyl]-2-(2'''-oxo-but-3'''-yn-1'''-yl)benzene
CAS No.:944382-58-5
Molecular Formula:C₁₇H₁₅BrO₂
Molecular Weight:331.209
Hs Code.:

Synonyms:1-[5'-(3''-bromo-propan-1''-yl)-2'-furanyl]-2-(2'''-oxo-but-3'''-yn-1'''-yl)benzene

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Chemical Property of 1-[5'-(3''-bromo-propan-1''-yl)-2'-furanyl]-2-(2'''-oxo-but-3'''-yn-1'''-yl)benzene

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Technology Process of 1-[5'-(3''-bromo-propan-1''-yl)-2'-furanyl]-2-(2'''-oxo-but-3'''-yn-1'''-yl)benzene

There total 7 articles about 1-[5'-(3''-bromo-propan-1''-yl)-2'-furanyl]-2-(2'''-oxo-but-3'''-yn-1'''-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 944382-57-4
1-[5'-(3''-bromo-propan-1''-yl)-2'-furanyl]-2-(2'''-hydroxybut-3'''-yn-1'''-yl)benzene

: 944382-58-5
1-[5'-(3''-bromo-propan-1''-yl)-2'-furanyl]-2-(2'''-oxo-but-3'''-yn-1'''-yl)benzene

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 ℃;
DOI:10.1016/S0040-4039(97)10437-3

Reference yield:

: 40400-15-5
2-(2-iodophenyl)acetonitrile

: 944382-58-5
1-[5'-(3''-bromo-propan-1''-yl)-2'-furanyl]-2-(2'''-oxo-but-3'''-yn-1'''-yl)benzene

Guidance literature:: Multi-step reaction with 6 steps

1: 1.9 g / (bis)-triphenylphosphine palladium (II) chloride / pentane; tetrahydrofuran / 16 h / Heating

2: 75 percent / tetra-n-butylammonium fluoride; p-toluenesulphonic acid / tetrahydrofuran / 12 h / 0 - 20 °C

3: 85 percent / triphenylphosphine; carbon tetrabromide / CH₂Cl₂ / 0.5 h / 0 °C

4: di-iso-butylaluminium hydride / toluene / 4.5 h / -78 - 0 °C

5: 0.38 g / tetrahydrofuran / 2 h / -78 - 20 °C

6: 50 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 - 20 °C

With diisobutylaluminum hydride; carbon tetrabromide; tetrabutyl ammonium fluoride; Dess-Martin periodane; toluene-4-sulfonic acid; triphenylphosphine; (bis)-triphenylphosphine palladium (II) chloride; In tetrahydrofuran; dichloromethane; toluene; pentane; 1: Stille coupling reaction;
DOI:10.1039/b703373g

Reference yield:

: tert-Butyl-diphenyl-[3-(5-tributylstannanyl-furan-2-yl)-propoxy]-silane

: 944382-58-5
1-[5'-(3''-bromo-propan-1''-yl)-2'-furanyl]-2-(2'''-oxo-but-3'''-yn-1'''-yl)benzene

Guidance literature:: Multi-step reaction with 6 steps

1: 1.9 g / (bis)-triphenylphosphine palladium (II) chloride / pentane; tetrahydrofuran / 16 h / Heating

2: 75 percent / tetra-n-butylammonium fluoride; p-toluenesulphonic acid / tetrahydrofuran / 12 h / 0 - 20 °C

3: 85 percent / triphenylphosphine; carbon tetrabromide / CH₂Cl₂ / 0.5 h / 0 °C

4: di-iso-butylaluminium hydride / toluene / 4.5 h / -78 - 0 °C

5: 0.38 g / tetrahydrofuran / 2 h / -78 - 20 °C

6: 50 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 - 20 °C

With diisobutylaluminum hydride; carbon tetrabromide; tetrabutyl ammonium fluoride; Dess-Martin periodane; toluene-4-sulfonic acid; triphenylphosphine; (bis)-triphenylphosphine palladium (II) chloride; In tetrahydrofuran; dichloromethane; toluene; pentane; 1: Stille coupling reaction;
DOI:10.1039/b703373g