4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyric acid

Base Information

Chemical Name:4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyric acid
CAS No.:150461-04-4
Molecular Formula:C₃₆H₃₅ClN₂O₃S
Molecular Weight:611.205
Hs Code.:

Synonyms:4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyric acid

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Chemical Property of 4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyric acid

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Technology Process of 4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyric acid

There total 10 articles about 4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150461-03-3
4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyronitrile

: 150461-04-4
4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyric acid

Guidance literature:: With potassium hydroxide; 2-methoxy-ethanol; ethylene glycol; at 150 ℃; for 1.5h; Yield given;
DOI:10.1021/jm00071a008

Reference yield:

: 146775-28-2
2-chloromethyl-5-phenylpyridine

: 150461-04-4
4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / NaH / dimethylformamide / 1 h

2: LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: Et₃N / CH₂Cl₂ / 1 h / -78 - 20 °C

4: dimethylformamide; dimethylsulfoxide / 1 h / 125 °C

5: ethylene glycol, 2-methoxyethanol, 8 N KOH / 1.5 h / 150 °C

With potassium hydroxide; lithium aluminium tetrahydride; 2-methoxy-ethanol; sodium hydride; ethylene glycol; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008

Reference yield:

: 144397-00-2
methyl 3-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

: 150461-04-4
4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / NaH / dimethylformamide / 1 h

2: LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: Et₃N / CH₂Cl₂ / 1 h / -78 - 20 °C

4: dimethylformamide; dimethylsulfoxide / 1 h / 125 °C

5: ethylene glycol, 2-methoxyethanol, 8 N KOH / 1.5 h / 150 °C

With potassium hydroxide; lithium aluminium tetrahydride; 2-methoxy-ethanol; sodium hydride; ethylene glycol; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008