(S)-N-[(3-(3-fluoro-4-((N-4-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl] 2-t-butoxycarbonylamino propionamide

Base Information

Chemical Name:(S)-N-[(3-(3-fluoro-4-((N-4-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl] 2-t-butoxycarbonylamino propionamide
CAS No.:623169-95-9
Molecular Formula:C₂₄H₃₄FN₅O₇
Molecular Weight:523.562
Hs Code.:

Synonyms:(S)-N-[(3-(3-fluoro-4-((N-4-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl] 2-t-butoxycarbonylamino propionamide

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Chemical Property of (S)-N-[(3-(3-fluoro-4-((N-4-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl] 2-t-butoxycarbonylamino propionamide

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Technology Process of (S)-N-[(3-(3-fluoro-4-((N-4-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl] 2-t-butoxycarbonylamino propionamide

There total 2 articles about (S)-N-[(3-(3-fluoro-4-((N-4-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl] 2-t-butoxycarbonylamino propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (S)-N-[(3-(3-fluoro-4-((N-4-benzyloxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl]-2-t-butoxycarbonylamino propionamide

: 623169-95-9
(S)-N-[(3-(3-fluoro-4-((N-4-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl] 2-t-butoxycarbonylamino propionamide

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In methanol; dichloromethane; water; for 7h; Product distribution / selectivity; Heating / reflux;

Reference yield: 63.0%

: 3744-87-4,7764-95-6,15761-38-3
N-t-butyloxycarbonyl-DL-alanine

: 221201-56-5
(S)-N-[(3-(3-fluoro-4-((N-4-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl]amine

: 623169-95-9
(S)-N-[(3-(3-fluoro-4-((N-4-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl] 2-t-butoxycarbonylamino propionamide

Guidance literature:: N-t-butyloxycarbonyl-DL-alanine; (S)-N-[(3-(3-fluoro-4-((N-4-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl]amine; In dichloromethane; at 0 - 5 ℃; for 0.5h;

With dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 2.5h; Product distribution / selectivity;