9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine

Base Information

Chemical Name:9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine
CAS No.:301826-29-9
Molecular Formula:C₁₈H₁₈ClFN₄O₂
Molecular Weight:376.818
Hs Code.:

9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine

Synonyms:9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine

Suppliers and Price of 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine

There total 3 articles about 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 149712-96-9
2-fluoro-6-chloropurine

: 301826-40-4
1-O-acetyl-3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-D-glycero-tetrofuranose

: 301826-29-9
9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; 1,2-dichloro-ethane; at 20 ℃; for 2h;
DOI:10.1016/S0008-6215(00)00005-7

Reference yield:

: 220569-97-1
3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-D-glycero-tetrofuranose

: 301826-29-9
9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine

Guidance literature:: Multi-step reaction with 2 steps

1: 89.2 percent / pyridine

2: 56 percent / (CH₃)3SiOTf / CH₂Cl₂; 1,2-dichloro-ethane / 2 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; pyridine; In dichloromethane; 1,2-dichloro-ethane; 1: Acetylation / 2: Alkylation;
DOI:10.1016/S0008-6215(00)00005-7

Reference yield:

: 220569-96-0
ethyl (R)-3-benzyloxymethyl-3-methyl-4-oxobutyrate

: 301826-29-9
9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-β-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine and 9-[3-C-(benzyloxymethyl)-2,3-dideoxy-3-C-methyl-α-D-glycero-tetrofuranosyl]-6-chloro-2-fluoropurine

Guidance literature:: Multi-step reaction with 3 steps

1: 67.2 percent / DIBAL-H / toluene / 3 h / -78 °C

2: 89.2 percent / pyridine

3: 56 percent / (CH₃)3SiOTf / CH₂Cl₂; 1,2-dichloro-ethane / 2 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; diisobutylaluminium hydride; pyridine; In dichloromethane; 1,2-dichloro-ethane; toluene; 1: Reduction / 2: Acetylation / 3: Alkylation;
DOI:10.1016/S0008-6215(00)00005-7