3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propan-1-ol

Base Information

• Chemical Name: 3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propan-1-ol
• CAS No.: 161557-67-1
• Molecular Formula: C₂₁H₂₃FN₂O₂
• Molecular Weight: 354.424

Synonyms:3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propan-1-ol

Chemical Property of 3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propan-1-ol

Chemical Property:

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Technology Process of 3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propan-1-ol

There total 3 articles about 3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propionic acid (161557-66-0) → 3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propan-1-ol (161557-67-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; toluene; at 0 ℃; for 0.333333h;

DOI:10.1016/S0223-5234(99)80009-9

Reference yield:

2-phenylacrylic acid (492-38-6) → 3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propan-1-ol (161557-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / propan-2-ol / 3 h / Heating

2: 94 percent / LiAlH₄ / toluene; tetrahydrofuran / 0.33 h / 0 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; isopropyl alcohol; toluene;

DOI:10.1016/S0223-5234(99)80009-9

Reference yield:

6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole (84163-77-9) → 3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propan-1-ol (161557-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / propan-2-ol / 3 h / Heating

2: 94 percent / LiAlH₄ / toluene; tetrahydrofuran / 0.33 h / 0 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; isopropyl alcohol; toluene;

DOI:10.1016/S0223-5234(99)80009-9

upstream raw materials:

3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-phenyl-propionic acid

2-phenylacrylic acid

6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole

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