((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone

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Chemical Name:((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone
CAS No.:1286756-60-2
Molecular Formula:C₁₉H₁₅F₆N₅O₃
Molecular Weight:475.35
Hs Code.:

Synonyms:((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone

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Chemical Property of ((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone

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Technology Process of ((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone

There total 11 articles about ((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1286756-59-9
(1R,2S)-2',4',5'-trifluoro-2-nitro-1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid

: 486460-21-3
3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

: 1286756-60-2
((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 0 - 23 ℃; Inert atmosphere;
DOI:10.1002/anie.201006204

Reference yield:

: 165047-24-5
2,4,5-trifluorobenzaldehyde

: 1286756-60-2
((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 5 h / 23 °C / Inert atmosphere

2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.25 h / -20 °C / Inert atmosphere

3.1: (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine / 1,4-dioxane / 0 - 23 °C / Inert atmosphere

4.1: caesium carbonate / dichloromethane / 3 h / 0 °C / Inert atmosphere

4.2: 0.25 h / 23 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / ethanol / 24 h / 23 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 6 h / 23 °C / Inert atmosphere

7.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0 - 23 °C / Inert atmosphere

With (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Michael reaction / 4.1: Michael condensation / 4.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1002/anie.201006204

Reference yield:

: 1286756-56-6
(R)-4-nitro-3-(2,4,5-trifluorophenyl)butanal

: 1286756-60-2
((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / dichloromethane / 3 h / 0 °C / Inert atmosphere

1.2: 0.25 h / 23 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 24 h / 23 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 6 h / 23 °C / Inert atmosphere

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0 - 23 °C / Inert atmosphere

With caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Michael condensation / 1.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1002/anie.201006204