5-[4'-(5-p-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole

Base Information

• Chemical Name: 5-[4'-(5-p-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole
• CAS No.: 882213-59-4
• Molecular Formula: C₄₂H₃₂N₆OS
• Molecular Weight: 668.822

Synonyms:5-[4'-(5-p-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole

Chemical Property of 5-[4'-(5-p-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole

Chemical Property:

Purity/Quality:

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Technology Process of 5-[4'-(5-p-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole

There total 5 articles about 5-[4'-(5-p-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-mercapto-5-(4-methylphenyl)-1,3,4-oxadiazole (31130-15-1) + N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole (133051-88-4) → 5-[4'-(5-p-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole (882213-59-4)

Guidance literature:

2-mercapto-5-(4-methylphenyl)-1,3,4-oxadiazole; With potassium carbonate; In acetone; for 0.5h; Heating;

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole; In acetone; Heating;

DOI:10.1002/jccs.200500079

Reference yield:

2-Cyano-4'-methylbiphenyl (114772-53-1) → 5-[4'-(5-p-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole (882213-59-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 96 percent / ZnCl₂; NaN₃ / dimethylformamide / 36 h / Heating

2.1: 91 percent / aq. NaOH / toluene / 3 h / 20 °C

3.1: 92 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / 8 h / Heating

4.1: K₂CO₃ / acetone / 0.5 h / Heating

4.2: 74 percent / acetone / Heating

With sodium hydroxide; N-Bromosuccinimide; sodium azide; potassium carbonate; zinc(II) chloride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1002/jccs.200500079

Reference yield:

N-(trityl)-5-[4?-(methyl)biphenyl-2-yl]-2H-tetrazole (133909-97-4) → 5-[4'-(5-p-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole (882213-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 92 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / 8 h / Heating

2.1: K₂CO₃ / acetone / 0.5 h / Heating

2.2: 74 percent / acetone / Heating

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; acetone;

DOI:10.1002/jccs.200500079

upstream raw materials:

2-mercapto-5-(4-methylphenyl)-1,3,4-oxadiazole

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

2-Cyano-4'-methylbiphenyl

N-(trityl)-5-[4?-(methyl)biphenyl-2-yl]-2H-tetrazole

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